Crystal structure of MLLT1 (ENL) YEATS domain in complexed with SGC-iMLLT (compound 92)

Discovery of an MLLT1/3 YEATS Domain Chemical Probe.

SMDNQCTVQVRLELGHRAQLRKKPTTEGFTHDWMVFVRGPEQCDIQHFVEKVVFWLHDSFPKPRRVCKEPPYKVEESGYA
GFIMPIEVHFKNKEEPRKVCFTYDLFLNLEGNPPVNHLRCEKLTFNNPTTEFRYKLLRAGGVMVMPEGAHHHHHH

25% PEG3350, 0.2M ammonium sulfate, 0.1M bis-tris pH 5.5 or 25% PEG Smear Medi-um, 0.1M citrate pH 5.5

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS

TRANSCRIPTION, YEATS domain, ENL, MLLT1, chemical probe, inhibitor, Structural Genomics, Structural Genomics Consortium, SGC

MDNQCTVQVRLELGHRAQLRKKPTTEGFTHDWMVFVRGPEQCDIQHFVEKVVFWLHDSFPKPRRVCKEPPYKVEESGYAG
FIMPIEVHFKNKEEPRKVCFTYDLFLNLEGNPPVNHLRCEKLTFNNPTTEFRYKLLRAGGVMVMPEGA