Crystal structure of the aminotransferase Aro8 from C. Albicans with ligands

Crystal structures of aminotransferases Aro8 and Aro9 from Candida albicans and structural insights into their properties.

MTSDTKPQAKDLTHLLSNESKARQTSPLKGIFKYYKQPGITFLGGGLPLSDYFPFEKVTADIPTPSFSGGIGAPIEGENK
TTIEVFKKAADNVPDQIELARSLQYGSTFGLPEFLQFIKEHTDMVHKVPYENWDVIVSVGNTEAWDSTLRTFCSKGDTIL
VEEYTFSSALESANGQGVNTVPVTMDEFGIIPEKLEELMSRWVGNKPKFLYTICTGQNPTGSSLSAERRKQIYDIACKYD
FLIIEDEPYYFLQMETYTKDKAAREGKAVHDHDEFLKALVPSFISLDVEGRVVRLDSFSKVLAPGLRLGWIVGQKDLLER
YVRLHEVSVQNPSGFSEALANALLRKWGHSGYLDWLIGLRAEYTHKRDVAIDALDQFVPKEVSSFNPPVAGMFFTVTLDA
SKHPKYKEFLEDPLKVEAAVHEQAIKQGCLLAPGSWFKAEGQSSPPQKNLPANPSHKTHIFFRGTYAAVPLDQLVVGLEK
FGKAVRAEFGL

Escherichia coli 'BL21-Gold(DE3)pLysS AG'

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS

MTSDTKPQAKDLTHLLSNESKARQTSPLKGIFKYYKQPGITFLGGGLPLSDYFPFEKVTADIPTPSFSGGIGAPIEGENK
TTIEVFKKAADNVPDQIELARSLQYGSTFGSPEFLQFIKEHTDMVHKVPYENWDVIVSVGNTEAWDSTLRTFCSKGDTIL
VEEYTFSSALESANGQGVNTVPVTMDEFGIIPEKLEELMSRWVGNKPKFLYTICTGQNPTGSSLSAERRKQIYDIACKYD
FLIIEDEPYYFLQMETYTKDKAAREGKAVHDHDEFLKALVPSFISLDVEGRVVRLDSFSKVLAPGLRLGWIVGQKDLLER
YVRLHEVSVQNPSGFSEALANALLRKWGHSGYLDWLIGLRAEYTHKRDVAIDALDQFVPKEVSSFNPPVAGMFFTVTLDA
SKHPKYKEFLEDPLKVEAAVHEQAIKQGCLLAPGSWFKAEGQSSPPQKNLPANPSHKTHIFFRGTYAAVPLDQLVVGLEK
FGKAVRAEFGL

binding site for Di-peptide PLP A 502 and PHE A 503

binding site for Di-peptide PLP B 502 and PHE B 503