Complex of Ovine Serum Albumin with diclofenac

2-[2,6-DICHLOROPHENYL)AMINO]BENZENEACETIC ACID

Structural Investigation of Diclofenac Binding to Ovine, Caprine, and Leporine Serum Albumins.

PETRA III, EMBL c/o DESY BEAMLINE P14 (MX2)

DTHKSEIAHRFNDLGEENFQGLVLIAFSQYLQQCPFDEHVKLVKELTEFAKTCVADESHAGCDKSLHTLFGDELCKVATL
RETYGDMADCCEKQEPERNECFLNHKDDSPDLPKLKPEPDTLCAEFKADEKKFWGKYLYEVARRHPYFYAPELLYYANKY
NGVFQECCQAEDKGACLLPKIDAMREKVLASSARQRLRCASIQKFGERALKAWSVARLSQKFPKADFTDVTKIVTDLTKV
HKECCHGDLLECADDRADLAKYICDHQDALSSKLKECCDKPVLEKSHCIAEVDKDAVPENLPPLTADFAEDKEVCKNYQE
AKDVFLGSFLYEYSRRHPEYAVSVLLRLAKEYEATLEDCCAKEDPHACYATVFDKLKHLVDEPQNLIKKNCELFEKHGEY
GFQNALIVRYTRKAPQVSTPTLVEISRSLGKVGTKCCAKPESERMPCTEDYLSLILNRLCVLHEKTPVSEKVTKCCTESL
VNRRPCFSDLTLDETYVPKPFDEKFFTFHADICTLPDTEKQIKKQTALVELLKHKPKATDEQLKTVMENFVAFVDKCCAA
DDKEGCFVLEGPKLVASTQAALA

Removing one DIF (diclofenac) molecule and replacing it by LMR - ligand from crystallization solution.

HYDROGENS HAVE BEEN USED IF PRESENT IN THE INPUT

Ovine serum albumin, Sheep serum albumin, diclofenac, nonsteroidal anti-inflammatory drugs, TRANSPORT PROTEIN