Crystal Structure of Human APRT wild type in complex with IMP

Structural basis for substrate selectivity and nucleophilic substitution mechanisms in human adenine phosphoribosyltransferase catalyzed reaction.

DSELQLVEQRIRSFPDFPTPGVVFRDISPVLKDPASFRAAIGLLARHLKATHGGRIDYIAGLDSRGFLFGPSLAQELGLG
CVLIRKRGKLPGPTLWASYSLEYGKAELEIQKDALEPGQRVVVVDDLLATGGTMNAACELLGRLQAEVLECVSLVELTSL
KGREKLAPVPFFSLLQYE

protein bought from Euromedex, cat# ATGP0483

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS