Crystal Structure of the Uperin-3.5 peptide from Uperoleia mjobergii forming cross-alpha fibril
The amphibian antimicrobial peptide uperin 3.5 is a cross-alpha /cross-beta chameleon functional amyloid.
Uperin-3.5 full-length, UNP residues 1-17
Reservoir contained 0.1 M KSCN, 0.1 M MES 6.03 pH, 20 %v/v Jeff 600 with cryo-protection of 20% ethylene glycol
The fibrils were visualized via TEM and fiber diffraction.
HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS U VALUES : REFINED INDIVIDUALLY
cross-alpha, fibril, amyloid-like, mating alpha-helical sheets, PROTEIN FIBRIL