Crystal Structure of KDM4D with tetrazole ligand GF057

4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID

Crystal Structure of KDM4D with tetrazole ligand

JmjC domain-containing histone demethylation protein 3D,Jumonji domain-containing protein 2D

AQNPNCNIMIFHPTKEEFNDFDKYIAYMESQGAHRAGLAKIIPPKEWKARETYDNISEILIATPLQQVASGRAGVFTQYH
KKKKAMTVGEYRHLANSKKYQTPPHQNFEDLERKYWKNRIYNSPIYGADISGSLFDENTKQWNLGHLGTIQDLLEKECGV
VIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHLGEPKTWYVVPPEHGQRLERLARELFPGSSRGCGAFLRHKVALIS
PTVLKENGIPFNRITQEAGEFMVTFPYGYHAGFNHGFNCAEAINFATPRWIDYGKMASQCSCGEARVTFSMDAFVRILQP
ERYDLWKRGQ

100mM HEPES, 180mM ammonium sulphate, 24% PEG 3350

KDM4D, ligand binding, ligand optimization, drug development, tetrazole, inhibitor design, cancer, epigenetics, OXIDOREDUCTASE