Crystal structure of Papaver somniferum tyrosine decarboxylase in complex with L-tyrosine

2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.

(2S)-2-amino-6-[[3-hydroxy-2-methyl-5-(phosphonooxymethyl)pyridin-4-yl]methylideneamino]hexanoic acid

Structural basis for divergent and convergent evolution of catalytic machineries in plant aromatic amino acid decarboxylase proteins.

Structural basis for independent origins of new catalytic machineries in plant AAAD proteins

MGSLPTNNLESISLCSQNPLDPDEFRRQGHMIIDFLADYYKNVEKYPVRSQVEPGYLKKRLPESAPYNPESIETILEDVT
NDIIPGLTHWQSPNYFAYFPSSGSIAGFLGEMLSTGFNVVGFNWMSSPAATELESIVMNWLGQMLTLPKSFLFSSDGSSG
GGGVLQGTTCEAILCTLTAARDKMLNKIGRENINKLVVYASDQTHCALQKAAQIAGINPKNVRAIKTSKATNFGLSPNSL
QSAILADIESGLVPLFLCATVGTTSSTAVDPIGPLCAVAKLYGIWVHIDAAYAGSACICPEFRHFIDGVEDADSFSLNAH
KWFFTTLDCCCLWVKDSDSLVKALSTSPEYLKNKATESKQVIDYKDWQIALSRRFRSMKLWLVLRSYGVANLRTFLRSHV
KMAKHFQGLIGMDNRFEIVVPRTFAMVCFRLKPTAIFKQKIVDNDYIEDQTNEVNVKLLESVNASGKIYMTHAVVGGVYM
IRFAVGATLTEERHVTGAWKVVQEHTDAILGA

MGSLPTNNLESISLCSQNPLDPDEFRRQGHMIIDFLADYYKNVEKYPVRSQVEPGYLKKRLPESAPYNPESIETILEDVT
NDIIPGLTHWQSPNYFAYFPSSGSIAGFLGEMLSTGFNVVGFNWMSSPAATELESIVMNWLGQMLTLPKSFLFSSDGSSG
GGGVLQGTTCEAILCTLTAARDKMLNKIGRENINKLVVYASDQTHCALQKAAQIAGINPKNVRAIKTSKATNFGLSPNSL
QSAILADIESGLVPLFLCATVGTTSSTAVDPIGPLCAVAKLYGIWVHIDAAYAGSACICPEFRHFIDGVEDADSFSLNAH
(LLP)WFFTTLDCCCLWVKDSDSLVKALSTSPEYLKNKATESKQVIDYKDWQIALSRRFRSMKLWLVLRSYGVANLRTFL
RSHVKMAKHFQGLIGMDNRFEIVVPRTFAMVCFRLKPTAIFKQKIVDNDYIEDQTNEVNVKLLESVNASGKIYMTHAVVG
GVYMIRFAVGATLTEERHVTGAWKVVQEHTDAILGA

1.2 M ammonium Sulfate 0.1 Bis Tris pH 5.0 and 1% w/v PEG 3350

National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)

Aromatic Amino Acid Decarboxylase, LYASE

MGSLPTNNLESISLCSQNPLDPDEFRRQGHMIIDFLADYYKNVENYPVRSQVEPGYLKKRLPESAPYNPESIETILEDVT
NDIIPGLTHWQSPNYFAYFPSSGSIAGFLGEMLSTGFNVVGFNWMSSPAATELESIVMNWLGQMLTLPKSFLFSSDGSSG
GGGVLQGTTCEAILCTLTAARDKMLNKIGRENINKLVVYASNQTHCALQKAAQIAGINPKNVRAIKTSKATNFGLSPNSL
QSAILADIESGLVPLFLCATVGTTSSTAVDPIGPLCAVAKLYGIWVHIDAAYAGSACICPEFRHFIDGVEDADSFSLNAH
KWFFTTLDCCCLWVKDSDSLVKALSTSAEYLKNKATESKQVIDYKDWQIALSRRFRSMKLWLVLRSYGVANLRTFLRSHV
KMAKHFQGLMGMDNRFEIVVPRTFAMVCFRLKPAAIFKQKIVDNDYIEDQTNEVNAKLLESVNASGKIYMTHAVVGGVYM
IRFAVGATLTEERHVTGAWKVVQEHTDAILGA