Structure of BDBV GPcl in complex with the pan-ebolavirus mAb ADI-15878

N-acetyl-beta-D-glucosamine; 2-acetamido-2-deoxy-beta-D-glucose; 2-acetamido-2-deoxy-D-glucose; 2-acetamido-2-deoxy-glucose; N-ACETYL-D-GLUCOSAMINE

Structural Basis of Pan-Ebolavirus Neutralization by a Human Antibody against a Conserved, yet Cryptic Epitope.

IPLGVVHNNTLQVSDIDKLVCRDKLSSTSQLASVGLNLEGNGVATDVPTATKRWGFRAGVPPKVVNYEAGEWAENCYNLD
IKKADGSECLPEAPEGVRGFPRCRYVHKVSGTGPCPEGYAFHKEGAFFLYDRLASTIIYRSTTFSEGVVAFLILPETKKD
FF

EITLRTQAKCNPNLHYWTTQDEGAAIGLAWIPYFGPAAEGIYTEGIMHNQNGLICGLRQLANETTQALQLFLRATTELRT
FSILNRKAIDFLLQRWGGTCHILGPDCCIEP

QVQLVQSGVTLVQPGGSLRVSCAASGFTFSSYAMSWVRQAPGKGLEWVSAISGLGGSTYYADSVKGRFTISRDNSKNTLY
LQMNSLRAEDTAVYYCAKDHRVWAAGYHFDYWGQGALVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT
VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDLEVDDDD

DIVLTQSPSTLSASVGDRVTITCRASQSISSWLAWYQQKPGEAPKLLISDASSLESGVPSRFSGSGSGTEFTLTISSLQP
DDFATYYCQQYYSSPTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQE
SVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC

2% Tacsimate pH 8.0, 100 mM Tris pH 8.5, and 16% PEG 3350

National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)

mAb, GP, glycoprotein, Ebola, EBOV, antibody, BDBV, bundibugyo, neutralization, immune, bnAb, complex, filovirus, VIRAL PROTEIN, VIRAL PROTEIN-immune system complex

IPLGVVHNNTLQVSDIDKLVCRDKLSSTSQLKSVGLNLEGNGVATDVPTATKRWGFRAGVPPKVVNYEAGEWAENCYNLD
IKKADGSECLPEAPEGVRGFPRCRYVHKVSGTGPCPEGYAFHKEGAFFLYDRLASTIIYRSTTFSEGVVAFLILPETKKD
FF