Shooting three inflammatory targets with a single bullet: Novel multi-targeting anti-inflammatory glitazones.

Double Si with sagittaly bent second crystal

Cys 285 was modified by BME adduct in protein buffer
Peroxisome proliferator-activated receptor gamma

PPAR-gamma,Nuclear receptor subfamily 1 group C member 3

NPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQG
(CME)QFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPF
GDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMT
DLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY

NPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQG
CQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFM
EPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQ
IVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY

PPAR, nuclear receptor, transcription factor, ligand binding domain, TRANSCRIPTION