Mechanism of cellular recognition by PCV2

Porcine Circovirus 2 Uses a Multitude of Weak Binding Sites To Interact with Heparan Sulfate, and the Interactions Do Not Follow the Symmetry of the Capsid.

(4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid)

MTYPRRRYRRRRHRPRSHLGQILRRRPWLVHPRHRYRWRRKNGIFNTRLSRTFGYTIKRTTVKTPSWAVDMMRFNINDFL
PPGGGSNPRSVPFEYYRIRKVKVEFWPCSPITQGDRGVGSSAVILDDNFVTKATALTYDPYVNYSSRHTITQPFSYHSRY
FTPKPVLDSTIDYFQPNNKRNQLWLRLQTAGNVDHVGLGTAFENSIYDQEYNIRVTMYVQFREFNLKDPPLNP

National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)

Particles assemble in the nucleus of infected cells.
Cryo-EM image reconstruction at 3.2Angstrom resolution