Crystal structure of HIV-1 Protease NL4-3 I84V Mutant in complex with darunavir

Structural Adaptation of Darunavir Analogues against Primary Mutations in HIV-1 Protease.

PQITLWKRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYDQILIEICGHKAIGTVLVGPT
PVNVIGRNLLTQIGCTLNF

23-24% (w/v) Ammonium Sulfate, 0.1M Bis-Tris-Methane-HCl Buffer pH 5.5

National Institutes of Health/National Human Genome Research Institute (NIH/NHGRI)

HIV, Protease, NL4-3, DRUG RESISTANCE, PROTEASE INHIBITOR, HYDROLASE INHIBITOR COMPLEX, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR complex

PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYDQILIEICGHKAIGTVLVGPT
PVNVIGRNLLTQIGCTLNF