How C-terminal additions to insulin B-chain fragments create superagonists for T cells in mouse and human type 1 diabetes.

MEQVEQLPSILRVQEGSSASINCSYEDSASNYFPWYKQEPGENPKLIIDIRSNMERKQTQGLIVLLDKKAKRFSLHITDT
QPGDSAMYFCAASRRGSGGSNYKLTFGKGTLLTVTPNIQNPDPAVYQLRDSKSSDKSVCLFTDFDSQTNVSQSKDSDVYI
TDKCVLDMRSMDFKSNSAVAWSNKSDFACANAFNNSIIPEDTFFPSPESS

MAVTQSPRNKVAVTGGKVTLSCDQTNNHNNMYWYRQDTGHGLRLIHYSYGAGSTEKGDIPDGYKASRPSQKEFSLILELA
TPSQTSVYFCASGGLGGDEQYFGPGTRLTVLEDLKNVFPPEVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNG
KEVHSGVCTDPQPLKEQPALNDSRYALSSRLRVSATFWQNPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRA
D

14% PEG 3350, 100mM sodium acetate at pH6.0

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS

T cell receptor, Type 1 Diabetes, Autoimmunity, IMMUNE SYSTEM