2.5 Angstrom crystal structure of the N97S CaM mutant

Arrhythmia mutations in calmodulin cause conformational changes that affect interactions with the cardiac voltage-gated calcium channel.

GHMADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMK
DTDSEEEIREAFRVFDKDGSGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTAK

chain 'A' and ((resid -2 through 78 ) or (resid 501 through 502))

chain 'A' and ((resid 79 through 145 ) or (resid 503 through 504))

chain 'B' and ((resid 12 through 78 ) or (resid 501 through 502))

chain 'B' and ((resid 79 through 146 ) or (resid 503 through 504))

chain 'C' and ((resid -2 through 78 ) or (resid 501 through 502))

chain 'C' and ((resid 79 through 146 ) or (resid 503 through 504))

chain 'D' and ((resid -2 through 78 ) or (resid 501 through 502))

chain 'D' and ((resid 79 through 144 ) or (resid 503 through 504))

calmodulin, mutant, CALCIUM BINDING PROTEIN

MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDT
DSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTAK