Crystal structure of aspartate semialdehyde dehydrogenase from Blastomyces dermatitidis with p-benzoquinone

cyclohexa-2,5-diene-1,4-dione; QUINONE RING OF THE PLASTOQUINONE 9

Structural insights into inhibitor binding to a fungal ortholog of aspartate semialdehyde dehydrogenase.

MSTPSKKRCGVLGATGAVGTRFILLLEQSPLLELVAVGASERSAGKKYRDAVRWKQASPMPASVADLTVRRCAPSEFSDC
DIIFSGLDPVAAGDIEMAFLKANFAVFSNAKNYRLDPIVPLVVPLVNAGHIDVIPAQRKHYGLDKGLIVCNSNCAVVGLV
IPAKALIQKFGPIESVSMVTMQAVSGAGYPGVSSMDIFDNIVPFIPGEEGKIATESRKILGNLNPDLAGFSDQQPLQVSV
ACNRVPVLDGHTVCASLRFVNRPAPTASQVRDALREYKSEVQLLGCPSAPRQAIHVLDDVDRPQPRLDRDTEAGYACSVG
RIREDDSGVFDIQFVALSHNTVLGASGSSILNAESAILKGYIKLAAALEHHHHHH

0.2M Ammonium Citrate Tribasic pH 7.0, 18 % w/v PEG 3350

National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)

Rossman fold, Oxidoreductase, Antifungal inhibitor complex

MSTPSKKRCGVLGATGAVGTRFILLLEKSPLLELVAVGASERSAGKKYRDAVRWKQASPMPASVADLTVRRCAPSEFSDC
DIIFSGLDPVAAGDIEMAFLKANFAVFSNAKNYRLDPIVPLVVPLVNAGHIDVIPAQRKHYGLDKGLIVCNSNCAVVGLV
IPAKALIQKFGPIESVSMVTMQAVSGAGYPGVSSMDIFDNIVPFIPGEEGKIATESRKILGNLNPDLAGFSDQQPLQVSV
ACNRVPVLDGHTVCASLRFVNRPAPTASQVRDALREYKSEVQLLGCPSAPRQAIHVLDDVDRPQPRLDRDTEAGYACSVG
RIREDDSGVFDIQFVALSHNTVLGASGSSILNAESAILKGYI