Crystal structure of the TRPV2 ion channel

Conformational plasticity in the selectivity filter of the TRPV2 ion channel.

Transient receptor potential cation channel subfamily V member 2

TSPSSPPAFRLETSDGGQDGAEVDKAQLGYGAGPPPMESRFQDEDRNFPPQIKVNLNYRKGAGASQPDLNRFDRDRLFNV
VARGNPEDLAGLLEYLRRTSKYLTDSEYTEGSTGKTCLMKAVLNLQDGVNACIQPLLEIDRDSGNPQPLVNAQCTDEYYR
GHSALHIAIEKRSLQCVKLLVENGANVHAKACGHFFQKNQDTCFYFGELPLSLAACTKQWDVVNYLLENPHQPASLQAQD
SLGNTVLHALVMIADDSAENSALVVRMYDGLLQAGARLCPNVQLEGIPNLEGLTPLKLAAKEGKIEIFKHILQREFSAPC
QSLSRKFTEWCYGPVRVSLYDLASVDSWEENSVLEIIAFHSRSPHRHRMVVLEPLNKLLQAKWDRLIPRFCFNFLCYLVY
MLIFTAVAYHQPALEKQGFPPLKATAGNSMLLLGHILILLGGVYLLLGQLWYFWRRRLFIWISFMDSYFEILFLLQALLT
VLSQVLCFLAIEWYLPLLVSSLVLGWLNLLYYTRGFQHTGIYSVMIQKVILRDLLRFLLVYLVFLFGFAVALVSLSREAQ
NSRTPAGPNATEVGQPGAGQEDEAPPYRSILDASLELFKFTIGMGELAFQEQLRFRGVVLLLLLAYVLLTYVLLLNMLIA
LMSETVNSVATDSWSIWKLQKAISVLEMENGYWWCRRKKQRAGVMLTVGTRPDGSPDERWCFRVGEMNWATWEQTLPRTL
CEEPSGAAAPGVMKNPTPASQRGEDSASEEDHLPLQLLQSRDYKDDDDKAHHHHHH

National Institutes of Health/National Institute of Neurological Disorders and Stroke (NIH/NINDS)

TRPV2 structure has been determined before by cryo-EM (5an8). TRP channels assemble as tetramers.

Ion Channel, TRPV channel, MEMBRANE PROTEIN, ca2+ channel, temperature sensing ion channel, heat sensor, somatosensation.

TSPSSPPAFRLETSDGGQDGAEVDKAQLGYGAGPPPMESRFQDEDRNFPPQIKVNLNYRKGAGASQPDLNRFDRDRLFNV
VARGNPEDLAGLLEYLRRTSKYLTDSEYTEGSTGKTCLMKAVLNLQDGVNACIQPLLEIDRDSGNPQPLVNAQCTDEYYR
GHSALHIAIEKRSLQCVKLLVENGANVHAKACGHFFQKNQDTCFYFGELPLSLAACTKQWDVVNYLLENPHQPASLQAQD
SLGNTVLHALVMIADDSAENSALVVRMYDGLLQAGARLCPNVQLEGIPNLEGLTPLKLAAKEGKIEIFKHILQREFSAPC
QSLSRKFTEWCYGPVRVSLYDLASVDSWEENSVLEIIAFHSRSPHRHRMVVLEPLNKLLQAKWDRLIPRFCFNFLCYLVY
MLIFTAVAYHQPALEKQGFPPLKATAGNSMLLLGHILILLGGVYLLLGQLWYFWRRRLFIWISFMDSYFEILFLLQALLT
VLSQVLCFLAIEWYLPLLVSSLVLGWLNLLYYTRGFQHTGIYSVMIQKVILRDLLRFLLVYLVFLFGFAVALVSLSREAQ
NSRTPAGPNATEVGQPGAGQEDEAPPYRSILDASLELFKFTIGMGELAFQEQLRFRGVVLLLLLAYVLLTYVLLLNMLIA
LMSETVNSVATDSWSIWKLQKAISVLEMENGYWWCRRKKQRAGVMLTVGTRPDGSPDERWCFRVGEMNWATWEQTLPRTL
CEEPSGAAAPGVMKNPTPASQRGEDSASEEDHLPLQLLQSR