Crystal structure of human Enterovirus D68 RdRp in complex with NADPH

NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE

Structure of the enterovirus D68 RNA-dependent RNA polymerase in complex with NADPH implicates an inhibitor binding site in the RNA template tunnel.

GEIVSNEKSGVCINAPAKTKLQPSVFHQVFEGSKEPAVLNSKDPRLKTDFEEAIFSKYTGNKIMLMDEYMEEAVDHYVGC
LEPLDISIDPIPLESAMYGMDGLEALDLTTSAGFPYLLQGKKKRDIFNRQTRDTTEMTRMLEKYGVDLPFVTFVKDELRS
REKVEKGKSRLIEASSLNDSVAMRVAFGNLYATFHNNPGTATGSAVGCDPDVFWSKIPILLNGEIFAFDYTGYDASLSPV
WFACLKKVLIKLGYTHQTSFIDYLCHSVHLYKDRKYIVNGGMPSGSSGTSIFNTMINNIIIRTLLIRVYKGIDLDQFKMI
AYGDDVIASYPHKIDPGLLAEAGKHYGLIMTPADKGTSFVDTNWENVTFLKRYFRADDQYPFLIHPVMPMKEIHESIRWT
KDPRNTQDHVRSLCYLAWHNGEEAYNEFCRKIRSVPVGRALTLPAYSSLRRKWLDSF

0.1M Tris, PH 8.0, 3.5M NH4Cl, 10mM Chromic chroride hexahydrate,5mM NADPH

EVD68-RdRp, Complex, Inhibitor, NADPH-Na4, Structure-based design, RNA BINDING PROTEIN