Crystal structure of a synthase from Streptomyces sp. CL190 with dmaspp

DMASPP; DMAPP; DMADP; Dimethylallyl pyrophosphate; dimethylallyl diphosphate; isoprenyl pyrophosphate

Catalytic Role of Conserved Asparagine, Glutamine, Serine, and Tyrosine Residues in Isoprenoid Biosynthesis Enzymes.

LN2 cooled Si(111) double crystal monochromator

MTTLMLLPDGMRRWSEKNGVSLDDGYAAMGDKIIEFMGWAKEEGVKTLYITASSAANHGRPEAAVNTFMEAFTEVIRRCH
SQFKFDFSGSLDLVSEDYLTELSALRDKSDSESDFTLHYILGMSLSHEVVGIFNKLNGKIPEMTEEILAENAYVPTQVDY
IIRTGGAIRMSSFFPLMSPYAELHFSPVLFPDTTRADFDAALKDLRARDRRFGGYPA

substrate binding, Cyclolavandulyl diphosphate synthase, inhibitor, BIOSYNTHETIC PROTEIN

(chain A and (resseq 3:11 or resseq 13:22 or (resid 23 and (name N or name CA or name CB or name CG or name OD1 or name C or name O )) or resseq 24:30 or (resid 31 and (name N or name CA or name CB or name CG or name OD1 or name C or name O )) or resseq 32:45 or resseq 47:59 or resseq 61 or resseq 63:95 or resseq 97:111 or resseq 113 or (resid 115 and (name N or name CA or name CB or name CG or name CD2 or name C or name O )) or resseq 116:134 or resseq 136:145 or resseq 147:156 or resseq 158:159 or resseq 161:173 or (resid 174 and (name N or name CA or name CB or name CG or name CD1 or name C or name O )) or resseq 175:179 or resseq 181:184 or (resid 185 and (name N or name CA or name CB or name CG or name CD1 or name C or name O )) or resseq 186:196 or (resid 197 and (name N or name CA or name CB or name CG or name OD1 or name C or name O )) or resseq 198 or (resid 199 and (name N or name CA or name CB or name CG or name OD1 or name C or name O )) or resseq 200:202 or resseq 204:207))

(chain B and (resseq 3:11 or resseq 13:22 or (resid 23 and (name N or name CA or name CB or name CG or name OD1 or name C or name O )) or resseq 24:30 or (resid 31 and (name N or name CA or name CB or name CG or name OD1 or name C or name O )) or resseq 32:45 or resseq 47:59 or resseq 61 or resseq 63:95 or resseq 97:111 or resseq 113 or (resid 115 and (name N or name CA or name CB or name CG or name CD2 or name C or name O )) or resseq 116:134 or resseq 136:145 or resseq 147:156 or resseq 158:159 or resseq 161:173 or (resid 174 and (name N or name CA or name CB or name CG or name CD1 or name C or name O )) or resseq 175:179 or resseq 181:184 or (resid 185 and (name N or name CA or name CB or name CG or name CD1 or name C or name O )) or resseq 186:196 or (resid 197 and (name N or name CA or name CB or name CG or name OD1 or name C or name O )) or resseq 198 or (resid 199 and (name N or name CA or name CB or name CG or name OD1 or name C or name O )) or resseq 200:202 or resseq 204:207))

(chain C and (resseq 3:11 or resseq 13:22 or (resid 23 and (name N or name CA or name CB or name CG or name OD1 or name C or name O )) or resseq 24:30 or (resid 31 and (name N or name CA or name CB or name CG or name OD1 or name C or name O )) or resseq 32:45 or resseq 47:59 or resseq 61 or resseq 63:95 or resseq 97:111 or resseq 113 or (resid 115 and (name N or name CA or name CB or name CG or name CD2 or name C or name O )) or resseq 116:134 or resseq 136:145 or resseq 147:156 or resseq 158:159 or resseq 161:173 or (resid 174 and (name N or name CA or name CB or name CG or name CD1 or name C or name O )) or resseq 175:179 or resseq 181:184 or (resid 185 and (name N or name CA or name CB or name CG or name CD1 or name C or name O )) or resseq 186:196 or (resid 197 and (name N or name CA or name CB or name CG or name OD1 or name C or name O )) or resseq 198 or (resid 199 and (name N or name CA or name CB or name CG or name OD1 or name C or name O )) or resseq 200:202 or resseq 204:207))

(chain D and (resseq 3:11 or resseq 13:22 or (resid 23 and (name N or name CA or name CB or name CG or name OD1 or name C or name O )) or resseq 24:30 or (resid 31 and (name N or name CA or name CB or name CG or name OD1 or name C or name O )) or resseq 32:45 or resseq 47:59 or resseq 61 or resseq 63:95 or resseq 97:111 or resseq 113 or (resid 115 and (name N or name CA or name CB or name CG or name CD2 or name C or name O )) or resseq 116:134 or resseq 136:145 or resseq 147:156 or resseq 158:159 or resseq 161:173 or (resid 174 and (name N or name CA or name CB or name CG or name CD1 or name C or name O )) or resseq 175:179 or resseq 181:184 or (resid 185 and (name N or name CA or name CB or name CG or name CD1 or name C or name O )) or resseq 186:196 or (resid 197 and (name N or name CA or name CB or name CG or name OD1 or name C or name O )) or resseq 198 or (resid 199 and (name N or name CA or name CB or name CG or name OD1 or name C or name O )) or resseq 200:202 or resseq 204:207))

(chain E and (resseq 3:11 or resseq 13:22 or (resid 23 and (name N or name CA or name CB or name CG or name OD1 or name C or name O )) or resseq 24:30 or (resid 31 and (name N or name CA or name CB or name CG or name OD1 or name C or name O )) or resseq 32:45 or resseq 47:59 or resseq 61 or resseq 63:95 or resseq 97:111 or resseq 113 or (resid 115 and (name N or name CA or name CB or name CG or name CD2 or name C or name O )) or resseq 116:134 or resseq 136:145 or resseq 147:156 or resseq 158:159 or resseq 161:173 or (resid 174 and (name N or name CA or name CB or name CG or name CD1 or name C or name O )) or resseq 175:179 or resseq 181:184 or (resid 185 and (name N or name CA or name CB or name CG or name CD1 or name C or name O )) or resseq 186:196 or (resid 197 and (name N or name CA or name CB or name CG or name OD1 or name C or name O )) or resseq 198 or (resid 199 and (name N or name CA or name CB or name CG or name OD1 or name C or name O )) or resseq 200:202 or resseq 204:207))

(chain F and (resseq 3:11 or resseq 13:22 or (resid 23 and (name N or name CA or name CB or name CG or name OD1 or name C or name O )) or resseq 24:30 or (resid 31 and (name N or name CA or name CB or name CG or name OD1 or name C or name O )) or resseq 32:45 or resseq 47:59 or resseq 61 or resseq 63:95 or resseq 97:111 or resseq 113 or (resid 115 and (name N or name CA or name CB or name CG or name CD2 or name C or name O )) or resseq 116:134 or resseq 136:145 or resseq 147:156 or resseq 158:159 or resseq 161:173 or (resid 174 and (name N or name CA or name CB or name CG or name CD1 or name C or name O )) or resseq 175:179 or resseq 181:184 or (resid 185 and (name N or name CA or name CB or name CG or name CD1 or name C or name O )) or resseq 186:196 or (resid 197 and (name N or name CA or name CB or name CG or name OD1 or name C or name O )) or resseq 198 or (resid 199 and (name N or name CA or name CB or name CG or name OD1 or name C or name O )) or resseq 200:202 or resseq 204:207))

(chain G and (resseq 3:11 or resseq 13:22 or (resid 23 and (name N or name CA or name CB or name CG or name OD1 or name C or name O )) or resseq 24:30 or (resid 31 and (name N or name CA or name CB or name CG or name OD1 or name C or name O )) or resseq 32:45 or resseq 47:59 or resseq 61 or resseq 63:95 or resseq 97:111 or resseq 113 or (resid 115 and (name N or name CA or name CB or name CG or name CD2 or name C or name O )) or resseq 116:134 or resseq 136:145 or resseq 147:156 or resseq 158:159 or resseq 161:173 or (resid 174 and (name N or name CA or name CB or name CG or name CD1 or name C or name O )) or resseq 175:179 or resseq 181:184 or (resid 185 and (name N or name CA or name CB or name CG or name CD1 or name C or name O )) or resseq 186:196 or (resid 197 and (name N or name CA or name CB or name CG or name OD1 or name C or name O )) or resseq 198 or (resid 199 and (name N or name CA or name CB or name CG or name OD1 or name C or name O )) or resseq 200:202 or resseq 204:207))

(chain H and (resseq 3:11 or resseq 13:22 or (resid 23 and (name N or name CA or name CB or name CG or name OD1 or name C or name O )) or resseq 24:30 or (resid 31 and (name N or name CA or name CB or name CG or name OD1 or name C or name O )) or resseq 32:45 or resseq 47:59 or resseq 61 or resseq 63:95 or resseq 97:111 or resseq 113 or (resid 115 and (name N or name CA or name CB or name CG or name CD2 or name C or name O )) or resseq 116:134 or resseq 136:145 or resseq 147:156 or resseq 158:159 or resseq 161:173 or (resid 174 and (name N or name CA or name CB or name CG or name CD1 or name C or name O )) or resseq 175:179 or resseq 181:184 or (resid 185 and (name N or name CA or name CB or name CG or name CD1 or name C or name O )) or resseq 186:196 or (resid 197 and (name N or name CA or name CB or name CG or name OD1 or name C or name O )) or resseq 198 or (resid 199 and (name N or name CA or name CB or name CG or name OD1 or name C or name O )) or resseq 200:202 or resseq 204:207))