Crystal Structure of the complex between the vinculin D1 domain and alphaE-catenin

The force-sensing device region of alpha-catenin is an intrinsically disordered segment in the absence of intramolecular stabilization of the autoinhibitory form

ROTATED-INCLINED DOUBLE-CRYSTAL MONOCHROMATOR , SI (111)

102 kDa cadherin-associated protein,Alpha E-catenin,CAP102

GPMPVFHTRTIESILEPVAQQISHLVIMHEEGEVDGKAIPDLTAPVAAVQAAVSNLVRVGKETVQTTEDQILKRDMPPAF
IKVENACTKLVQAAQMLQSDPYSVPARDYLIDGSRGILSGTSDLLLTFDEAEVRKIIRVCKGILEYLTVAEVVETMEDLV
TYTKNLGPGMTKMAKMIDERQQELTHQEHRVMLVNSMNTVKELLPVLISAMKIFVTTKNSKNQGIEEALKNRNFTVEKMS
AEINEIIRVLQL

GPGELAYALNNFDKQIIVDPLSFSEERFRPSLEERLESIISGAALMADSSCTRDDRRERIVAECNAVRQALQDLLSEYMG
NAGRKERSDALNSAIDKMTKKT

100MM IMIDAZOLE, 0.5-0.7M POTASSIUM
TARTRATE, 0.35M SODIUM FORMATE

HYDROGENS HAVE BEEN USED IF PRESENT IN
THE INPUT

ADHERENS JUNCTION, CYTOSKELETON, CELL ADHESION

MPVFHTRTIESILEPVAQQISHLVIMHEEGEVDGKAIPDLTAPVAAVQAAVSNLVRVGKETVQTTEDQILKRDMPPAFIK
VENACTKLVQAAQMLQSDPYSVPARDYLIDGSRGILSGTSDLLLTFDEAEVRKIIRVCKGILEYLTVAEVVETMEDLVTY
TKNLGPGMTKMAKMIDERQQELTHQEHRVMLVNSMNTVKELLPVLISAMKIFVTTKNSKNQGIEEALKNRNFTVEKMSAE
INEIIRVLQL

GELAYALNNFDKQIIVDPLSFSEERFRPSLEERLESIISGAALMADSSCTRDDRRERIVAECNAVRQALQDLLSEYMGNA
GRKERSDALNSAIDKMTKKT