Cryo-EM structure of human respiratory complex I transmembrane arm

S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate

DIPHOSPHATIDYL GLYCEROL; BIS-(1,2-DIACYL-SN-GLYCERO-3-PHOSPHO)-1',3'-SN-GLYCEROL

Architecture of Human Mitochondrial Respiratory Megacomplex I2III2IV2.

Human respiratory complex I transmembrane arm

NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial

NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial

NADH dehydrogenase [ubiquinone] 1 subunit C2

NADH dehydrogenase [ubiquinone] iron-sulfur protein 5

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial

Complex I-49kD,CI-49kD,NADH-ubiquinone oxidoreductase 49 kDa subunit

Complex I-MWFE,CI-MWFE,NADH-ubiquinone oxidoreductase MWFE subunit

Complex I-B9,CI-B9,NADH-ubiquinone oxidoreductase B9 subunit

Complex I-B14.7,CI-B14.7,NADH-ubiquinone oxidoreductase subunit B14.7

Cell death regulatory protein GRIM-19,Complex I-B16.6,CI-B16.6,Gene associated with retinoic and interferon-induced mortality 19 protein,Gene associated with retinoic and IFN-induced mortality 19 protein,NADH-ubiquinone oxidoreductase B16.6 subunit

ACP,CI-SDAP,NADH-ubiquinone oxidoreductase 9.6 kDa subunit

Complex I-AGGG,CI-AGGG,NADH-ubiquinone oxidoreductase AGGG subunit

Complex I-B12,CI-B12,NADH-ubiquinone oxidoreductase B12 subunit

Complex I-SGDH,CI-SGDH,NADH-ubiquinone oxidoreductase SGDH subunit

Complex I-B17,CI-B17,NADH-ubiquinone oxidoreductase B17 subunit

Complex I-ASHI,CI-ASHI,NADH-ubiquinone oxidoreductase ASHI subunit

Complex I-PDSW,CI-PDSW,NADH-ubiquinone oxidoreductase PDSW subunit

Complex I-ESSS,CI-ESSS,NADH-ubiquinone oxidoreductase ESSS subunit,Neuronal protein 17.3,p17.3

Complex I-KFYI,CI-KFYI,NADH-ubiquinone oxidoreductase KFYI subunit

Complex I-B14.5b,CI-B14.5b,Human lung cancer oncogene 1 protein,HLC-1,NADH-ubiquinone oxidoreductase subunit B14.5b

Complex I-15 kDa,CI-15 kDa,NADH-ubiquinone oxidoreductase 15 kDa subunit

Complex I-MNLL,CI-MNLL,NADH-ubiquinone oxidoreductase MNLL subunit

Complex I-B15,CI-B15,NADH-ubiquinone oxidoreductase B15 subunit

Complex I-B22,CI-B22,LYR motif-containing protein 3,NADH-ubiquinone oxidoreductase B22 subunit

Complex I-19kD,CI-19kD,Complex I-PGIV,CI-PGIV,NADH-ubiquinone oxidoreductase 19 kDa subunit

Cell adhesion protein SQM1,Complex I-B18,CI-B18,NADH-ubiquinone oxidoreductase B18 subunit

Complex I-42kD,CI-42kD,NADH-ubiquinone oxidoreductase 42 kDa subunit

AARVGAFLKNAWDKEPVLVVSFVVGGLAVILPPLSPYFKYSVMINKATPYNYPVPVRDDGNMPDVPSHPQDPQGPSLEWL
KKL

APKVFRQYWDIPDGTDCHRKAYSTTSIASVAGLTAAAYRVTLNPPGTFLEGVAKVGQYTFTAAAVGAVFGLTTCISAHVR
EKPDDPLNYFLGGCAGGLTLGARTHNYGIGAAACVYFGIAASLVKMGRLEGWEVFAKPKV

GLSGYSMLAIGIGTLIYGHWSIMKWNRERRRLQIEDFEARIALLPLLQAETDRRTLQMLRENLEEEAIIMKDVPDWKVGE
SVFHTTRWVPPLIGELYGLRTTEEALHASHGFMWYT

PPLTLEGIQDRVLYVLKLYDKIDPEKLSVNSHFMKDLGLDSLDQVEIIMAMEDEFGFEIPDIDAEKLMCPQEIVDYIADK
KDVYE

KRLFVIRPSRFYDRRFLKLLRFYIALTGIPVAIFITLVNVFIGQAELAEIPEGYVPEHWEYYKHPISRWIARNFYDSPEK
IYERTMAVLQIEAEKAELRVKELEVRKLMHVRGDGPWYYYETIDKELIDHSPKATPDN

MTGYTPDEKLRLQQLRELRRRWLKDQELSPREPVLPPQKMGPMEKFWNKFLENKSPWRKMVHGVYKKSIFVFTHVLVPVW
IIHYYMKYHVSEKPYGIVEKKSRIFPGDTILETGEVIPPMKEFPDQHH

KDMFPGPYPRTPEERAAAAKKYNMRVEDYEPYPDDGMGYGDYPKLPDRSQHERDPWYSWDQPGLRLNWGEPMHWHLDMYN
RNRVDTSPTPVSWHVMCMQLFGFLAFMIFMCWVGDVYPVYQPVGPKQYPYNNLYLERGGDPSKEPERVVHYEI

MPDSWDKDVYPEPPRRTPVQPNPIVYMMKAFDLIVDRPVTLVREFIERQHAKNRYYYYHRQYRRVPDITECKEEDIMCMY
EAEMQWKRDYKVDQEIINIMQDRLKACQQREGQNYQQNCIKEVEQFTQVAKAYQDRYQDLGAYSSARKCLAKQRQRMLQE
RKAAKEAAAAT

PWQEDPEPEDENLYEKNPDSHGYDKDPVLDVWNMRLVFFFGVSIILVLGSTFVAYLPDYRMKEWSRREAERLVKYREANG
LPIMESNCFDPSKIQLP

MIARRNPEPLRFLPDEARSLPPPKLTDPRLLYIGFLGYCSGLIDNLIRRRPIATAGLHRQLLYITAFFFAGYYLVKREDY
LYAVRDREMFGYMKLHPEDFPEEDKKTYGEIFEKFHPIR

PFLDIQKRFGLNIDRWLTIQSGEQPYKMAGRCHAFEKEWIECAHGIGYTRAEKECKIEYDDFVECLLRQKTMRRAGTIRK
QRDKLIKEGKYTPPPHHIGKGEPR

MNPLAQPVIYSTIFAGTLITALSSHWFFTWVGLEMNMLAFIPVLTKKMNPRSTEAAIKYFLTQATASMILLMAILFNNML
SGQWTMTNTTNQYSSLMIMMAMAMKLGMAPFHFWVPEVTQGTPLTSGLLLLTWQKLAPISIMYQISPSLNVNLLLTLSIL
SIMAGSWGGLNQTQLRKILAYSSITHMGWMMAVLPYNPNMTILNLTIYIILTTTAFLLLNLNSSTTTLLLSRTWNKLTWL
TPLIPSTLLSLGGLPPLTGFLPKWAIIEEFTKNNSLIIPTIMATITLLNLYFYLRLIYSTSITLLPMSNNVKMKWQFEHT
KPTPFLPTLIALTTLLLPISPFMLMIL

MNFALILMTNTLLALLLMIITFWLPQLNGYMEKSTPYECGFDPMSPARVPFSMKFFLVAITFLLFDLEIALLLPLPWALQ
TTNLPLMVMSSLLLIIILALSLAYEWLQKGLDWAE

MPLIYMNIMLAFTISLLGMLVYRSHLMSSLLCLEGMMLSLFIMATLMTLNTHSLLANIMPIVMLVFAACEAAVGLALLVS
ISNTYGLDYVHNLNLLQ

MTMHTTMATLTLTSLIPPILTTLVNPNKKNSYPHYVKSIVASTFIISLFPTTMFMCLDQEVIISNWHWATTQTTQLSLSF
KLDYFSMMFIPVALFVTWSIMEFSLWYMNSDPNINQFFKYLLIFLITMLILVTANNLFQLFIGWEGVGIMSFLLISWWYA
RADANTAAIQAILYNRIGDIGFILALAWFILHSNSWDPQQMALLNANPSLTPLLGLLLAAAGKSAQLGLHPWLPSAMEGP
TPVSALLHSSTMVVAGIFLLIRFHPLAENNPLIQTLTLCLGAITTLFAAVCALTQNDIKKIVAFSTSSQLGLMMVTIGIN
QPHLAFLHICTHAFFKAMLFMCSGSIIHNLNNEQDIRKMGGLLKTMPLTSTSLTIGSLALAGMPFLTGFYSKDHIIETAN
MSYTNAWALSITLIATSLTSAYSTRMILLTLTGQPRFPTLTNINENNPTLLNPIKRLAAGSLFAGFLITNNISPASPFQT
TIPLYLKLTALAVTFLGLLTALDLNYLTNKLKMKSPLCTFYFSNMLGFYPSIMHRTIPYLGLLTSQNLPLLLLDLTWLEK
LLPKTISQHQISTSIITSTQKGMIKLYFLSFFFPLILTLLLIT

MMYALFLLSVGLVMGFVGFSSKPSPIYGGLVLIVSGVVGCVIILNFGGGYMGLMVFLIYLGGMMVVFGYTTAMAIEEYPE
AWGSGVEVLVSVLVGLAMEVGLVLWVKEYDGVVVVVNFNSVGSWMIYEGEGSGFIREDPIGAGALYDYGRWLVVVTGWTL
FVGVYIVIEIARGN

SFPKYKPSSLRTLPETLDPAEYNISPETRRAQAERLAIRAQLKREYLLQYNDPNRRGLIENPALLRWAYARTINVYPNFR
PTPKNSLMGALCGFGPLIFIYYIIKTERDRKEKLIQEGKLDRTFHLSY

PYLTHQQKVLRLYKRALRHLESWCVQRDKYRYFACLMRARFEEHKNEKDMAKATQLLKEAEEEFWYRQHPQPYIFPDSPG
GTSYERYDCYKVPEWCLDDWHPSEKAMYPDYFAKREQWKKLRRESWEREVKQLQEETPPGGPLTEALPPARKEGDLPPLW
WYIVTRPRERPM

MLKLIVPTIMLLPLTWLSKKHMIWINTTTHSLIISIIPLLFFNQINNNLFSCSLTFSSDPLTTPLLMLTTWLLPLTIMAS
QRHLSSEPLSRKKLYLSMLIFLQISLIMTFTATELIMFYIFFETTLIPTLAIITRWGNQPERLNAGTYFLFYTLVGSLPL
LIALIYTHNTLGSLNILLLTLTAQELSNSWANNLMWLAYTMAFMVKMPLYGLHLWLPKAHVEAPIAGSMVLAAVLLKLGG
YGMMRLTLILNPLTKHMAYPFLVLSLWGMIMTSSICLRQTDLKSLIAYSSISHMALVVTAILIQTPWSFTGAVILMIAHG
LTSSLLFCLANSNYERTHSRIMILSQGLQTLLPLMAFWWLLASLANLALPPTINLLGELSVLVTTFSWSNITLLLTGLNM
LVTALYSLYMFTTTQWGSLTHHINNMKPSFTRENTLMFMHLSPILLLSLNPDIITGFSS

MPMANLLLLIVPILIAMAFLMLTERKILGYMQLRKGPNVVGPYGLLQPFADAMKLFTKEPLKPATSTITLYITAPTLALT
IALLLWTPLPMPNPLVNLNLGLLFILATSSLAVYSILWSGWASNSNYALIGALRAVAQTISYEVTLAIILLSTLLMSGSF
NLSTLITTQEHLWLLLPSWPLAMMWFISTLAETNRAPFDLAEGESELVSGFNIEYAAGPFALFFMAEYTNIIMMNTLTTT
IFLGTTYDALSPELYTTYFVTKTLLLTSLFLWIRTAYPRFRYDQLMHLLWKNFLPLTLALLMWHVSMPITISSIPPQT

IVELPTLEELKVDEVKISSAVLKAAAHHYGAQCDKPNKEFMLCRWEEKDPRRCLEEGKLVNKCALDFFRQIKRHCAEPFT
EYWTCIDYTGQQLFRHCRKQQAKFDECVLDKLGWVRPDLGELSKVTKVKTDRPLPENPYHSRPRPDPSPEIEGDLQPATH
GSRFYFWTK

AHLVRRYLGDASVEPDPLQMPTFPPDYGFPERKEREMVATQQEMMDAQLRLQLRDYCAHHLIRLLKCKRDSFPNFLACKQ
ERHDWDYCEHRDYVMRMKEFERERRLLQRKKRREKKAAELAK

LRYGMWHFLLGDKASKRLTERSRVITVDGNICTGKGKLAKEIAEKLGFKHFPEAGIHYPDSTTGDGKPLATDYNGNCSLE
KFYDDPRSNDGNSYRLQSWLYSSRLLQYSDALEHLLTTGQGVVLERSIFSDFVFLEAMYNQGFIRKQCVDHYNEVKSVTI
CDYLPPHLVIYIDVPVPEVQRRIQKKGDPHEMKITSAYLQDIENAYKKTFLPEMSEKCEVLQYSAREAQDSKKVVEDIEY
LKFDKGPWLKQDNRTLYHLRLLVQDKFEVLNYTSIPIFLPEVTIGAHQTDRVLHQFRELPGRKYSPGYNTEVGDKWIWLK

National Science Fund for Distinguished Young Scholars

National Natural Science Foundation of China

NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial (E.C.1.6.5.3,1.6.99.3), NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1, NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3, NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11, NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13, Acyl carrier protein, mitochondrial, NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial, NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3, NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial, NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6, NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial, NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10, NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial, NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial, NADH dehydrogenase [ubiquinone] 1 subunit C2, NADH dehydrogenase [ubiquinone] iron-sulfur protein 5, NADH-ubiquinone oxidoreductase chain 2 (E.C.1.6.5.3), NADH-ubiquinone oxidoreductase chain 3 (E.C.1.6.5.3), NADH-ubiquinone oxidoreductase chain 4L (E.C.1.6.5.3), NADH-ubiquinone oxidoreductase chain 5 (E.C.1.6.5.3), NADH-ubiquinone oxidoreductase chain 6 (E.C.1.6.5.3), NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1, NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4, NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9, NADH-ubiquinone oxidoreductase chain 4 (E.C.1.6.5.3), NADH-ubiquinone oxidoreductase chain 1 (E.C.1.6.5.3), NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8, NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7, NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial
Homo sapiens, Oxidoreductase, Respiratory, Complex, ELECTRON TRANSPORT