Crystal structure of the medaka fish taste receptor T1r2a-T1r3 ligand binding domains in complex with L-alanine

N-acetyl-beta-D-glucosamine; 2-acetamido-2-deoxy-beta-D-glucose; 2-acetamido-2-deoxy-D-glucose; 2-acetamido-2-deoxy-glucose; N-ACETYL-D-GLUCOSAMINE

Structural basis for perception of diverse chemical substances by T1r taste receptors

QSTDQTSEFHLRGDYLIGGLFNIHYVAAANFQRPQAIDCSSKLFILPNYRRFQMMRFSVEEINNSSSLLPNVSLGYQMFD
HCSDIHSFPGIFKLLSVNDLIRPWEDASTGLPNAIGVVGPFTSTHALSIAPIFMTNLFPMVSYGCSGSVFSKENLYPSFL
RTVHSNKDVINAIVGIILNFNWRWVAFLYSDDDFGKDGLEQFKNKIEDSEICLAFYKAINVNTDYLQVFKQIEEQNIKVI
VVFAPKVYAEAVVESAVQLNVTNKVWIADDGWSLNKKLPSMNGIQNIGTVLGVAQPVVTIPGFTDFIYSAISQTDGGDTE
QKMFCNQKCNCSNLSVKSLLNADPSFSFPVYAAVYAIAHALHNTLRCGSDRCPKNITVHPHMILEELKKSNFTLLNQTVQ
FDENGDPKFGSLSVVFWNSSGNAEEVGSYHFQSSIHLSINKTKIKWFTNGEVPTSSGIEGR

SPNWFNNISTDLFSMPGDIKLGGLFPIKEQSNEVSNDLTKLNSVSCDSLNKDGLGRALVMKYAVEEINANSQLLPGVKLG
YKIYNTCRHSAVIVRPALSFLTEKSNGTLSVECNYTDYETDMVAVIGPQSSEMVTVIGKLLGFFLMPQISFGATSDKFSD
SLVYPSFFRTVPSDIRQVDAMVQLIKKFNWNWVAVVGSEEEYGQQGVQQFSKKAEDMGVCVAYQGLIPIYDDPKPAIQTI
INNIQTTEVKVVVVFSLVSPAVSFFEEVIKKNLTGVWIASSSWAISDKVYSLPNIDSIGTVIGFIDETETLELLSPFTEV
LFKKIHEASPTEKPEDPYNPCPECWSLSPANVSLVKEESVQRTAFSVYAAVYTVAHALHKLLECNSAACKWSSSTRLYPW
KLLEVLKEFSVNISNTSLKFDQNGNPNIGYSVIQRIWENQSLSSVGSYRSANLSINETLFKWYTNNSEKPESSGIEGR

EVQLQQSGPELVKPGASMKISCKASGYSFTGYSMNWVKQSHGKNLEWIGLINPYNGDTTYKQKFKGKATLTVDRSSSTAY
MELLRLTSEDSAVYYCARSGRGAPTTTTAWFTYWGQGTLVTVSAAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEP
VTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIVPRD

DIVLTQSPASLAVSLGQRATISCRASESVDSYGNSFMHWYQQKPGQPPILLISRASNLESGIPARFSGSGSRTDFTLTIN
PVEADDFATYYCQQTNEDPRTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQ
NGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNE

receptor, ligand binding, amino acid, venus-flytrap domain, SIGNALING PROTEIN-IMMUNE SYSTEM complex

QSTDQTSEFHLRGDYLIGGLFNIHYVAAANFQRPQAIDCSSKLFILPNYRRFQMMRFSVEEINNSSSLLPNVSLGYQMFD
HCSDIHSFPGIFKLLSVNDLIRPWEDASTGLPNAIGVVGPFTSTHALSIAPIFMTNLFPMVSYGCSGSVFSKENLYPSFL
RTVHSNKDVINAIVGIILNFNWRWVAFLYSDDDFGKDGLEQFKNKIEDSEICLAFYKAINVNTDYLQVFKQIEEQNIKVI
VVFAPKVYAEAVVESAVQLNVTNKVWIADDGWSLNKKLPSMNGIQNIGTVLGVAQPVVTIPGFTDFIYSAISQTDGGDTE
QKMFCNQKCNCSNLSVKSLLNADPSFSFPVYAAVYAIAHALHNTLRCGSDRCPKNITVHPHMILEELKKSNFTLLNQTVQ
FDENGDPKFGSLSVVFWNSSGNAEEVGSYHFQSSIHLSINKTKIKWFTNGEVPTS

SPNWFNNISTDLFSMPGDIKLGGLFPIKEQSNEVSNDLTKLNSVSCDSLNKDGLGRALVMKYAVEEINANSQLLPGVKLG
YKIYNTCRHSAVIVRPALSFLTEKSNGTLSVECNYTDYETDMVAVIGPQSSEMVTVIGKLLGFFLMPQISFGATSDKFSD
SLVYPSFFRTVPSDIRQVDAMVQLIKKFNWNWVAVVGSEEEYGQQGVQQFSKKAEDMGVCVAYQGLIPIYDDPKPAIQTI
INNIQTTEVKVVVVFSLVSPAVSFFEEVIKKNLTGVWIASSSWAISDKVYSLPNIDSIGTVIGFIDETETLELLSPFTEV
LFKKIHEASPTEKPEDPYNPCPECWSLSPANVSLVKEESVQRTAFSVYAAVYTVAHALHKLLECNSAACKWSSSTRLYPW
KLLEVLKEFSVNISNTSLKFDQNGNPNIGYSVIQRIWENQSLSSVGSYRSANLSINETLFKWYTNNSEKPES