DNA polymerase beta substrate complex with incoming 5-FodCTP

2'-deoxy-5-formylcytidine 5'-(tetrahydrogen triphosphate)

Structures of a DNA Polymerase Inserting Therapeutic Nucleotide Analogues.

DNA (5'-D(*CP*CP*GP*AP*CP*GP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3')

DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3')

MSKRKAPQETLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLPGVGTKIAEKIDEFLATG
KLRKLEKIRQDDTSSSINFLTRVSGIGPSAARKFVDEGIKTLEDLRKNEDKLNHHQRIGLKYFGDFEKRIPREEMLQMQD
IVLNEVKKVDSEYIATVCGSFRRGAESSGDMDVLLTHPSFTSESTKQPKLLHQVVEQLQKVHFITDTLSKGETKFMGVCQ
LPSKNDEKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRPLGVTGVAGEPLPVDSEKDIF
DYIQWKYREPKDRSE

50 mM imidazole, pH 7.5, 16% PEG3350, and 350 mM sodium acetate.

National Institutes of Health/National Institute of Environmental Health Sciences (NIH/NIEHS)

DNA LIGASE/DNA, TRANSFERASE, DNA LIGASE-DNA, TRANSFERASE complex