Crystal structure of chalcone isomerase engineered from ancestral inference (ancR5)

Evolution of chalcone isomerase from a noncatalytic ancestor.

SHGMAVTKVTVDGIEFPPTITPPGSSKSLTLLGAGVRGIEIEAIQIKVTAIGVYAEPEVIASHLQKWKGKSASELVEDDG
FFKDLVQAPVEKLVKITMIKGLTGSQYGGAVEENIKDRLAALDKYSEAEEEALEEFREFFKTKSFPKGSVIFFHWSSPST
LQISVSTDGSLPEEAEATVENANVAAALLDVFLGKNSVSPSTKASVAEGISALLMKNKDEKEV

chalcone isomerase, naringenin, flavanone, ISOMERASE