Crystal Structure of Wild-type MalA', isomalbrancheamide B complex

Function and Structure of MalA/MalA', Iterative Halogenases for Late-Stage C-H Functionalization of Indole Alkaloids.

MAPTPKYTFTERAAAGNLSDAEILNSNNPTGSELPDESDVVVGGAGIHGLIYALHASKYKPNNLKISVIEKNTRPGYKIG
ESTLPIFYTWCKLHGISAAYLLRLFGLKDGLCFYFLDRENQGQYTDFCSVGAPGLVLASLQIERPMSELLFTILAQRNGV
NVYHGREVDFKSTVVQGGGQGNKIAVSRGKYDSTPKTIDSALFVDATGRFRQFCSKKAPRHRFDGWNCNAFWGYFTAPKD
ESKIPFDLYEGDHTNHLCFPEGWVWVIRLPSWEGSPIANLMDMVTYILECADAGVPGDELPSSEELARMFGLKFQWVTSI
GFAVRNDVKYPEDLSAYGTREAEQKFNYFVQKYELLQQFMSNFELIENLYGPGTTWFIRKTLAYQSPVVSGPGWLAIGDA
CGFTNPLYSPGINVGMSTSTWAAQLSHPIVEIGKSAPADAAESSIRKLLVPYDDYCKSLVPALEQMNRFNYVCYRDTRLG
PQVACLWQFFAGIERYLSDVNIETFAHYAIKWVWGAMVPEYQQVAQKCIEHIETVPLDERLPDAMVDELLAFSNRIKSAA
VAADDFSLRWDAILRSFDRSLNFVEGKTSRDIYTRQCSGCGAWLQLRPDWKKCHSCGLLGTEPQTAVTFDPPLTAEEEAL
LYAAWNTAPKYDPSKELKLPTPTRPAA

2 M ammonium sulfate, 0.2 M lithium sulfate, 0.1 M Bis-Tris pH 5.5, 5 mM cadmium chloride

National Institutes of Health/National Cancer Institute (NIH/NCI)

National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)

National Science Foundation (NSF, United States)

flavin-dependent halogenase, malbrancheamide, zinc, Zn, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex

MAPTPKYTFTERAAAGNLSDAEILNSNNPTGSELPDESDVVVGGAGIHGLIYALHASKYKPNNLKISVIEKNTRPGYKIG
ESTLPIFYTWCKLHGISAAYLLRLFGLKDGLCFYFLDRENQGQYTDFCSVGAPGLVLASLQIERPMSELLFTILAQRNGV
NVYHGREVDFKSTVVQGGGQGNKIAVSRGKYDSTPKTIDSALFVDATGRFRQFCSKKAPRHRFDGWNCNAFWGYFTAPKD
ESKIPFDLYEGDHTNHLCFPEGWVWVIRLPSWEGSLIANLMDMVTYILECADAGVPGDELPSSEELARMFGLKFQWVTSI
GFAVRNDVKYPEDLSAYGTREAEQKFNYFVQKYELLQQFMSNFELIENLYGPGTTWFIRKTLAYQSPVVSGPGWLAIGDA
CGFTNPLYSPGINVGMSTSTWAAQLSHRIVEIGKSAPADAAESSIRKLLVPYDDYCKSLVPALEQMNRFNYVCYRDTRLG
PQVACLWQFFAGIERYLSDVNIETFAHYAIKWVWGAMVPEYQQVAQKCIEHIETVPLDERLPDAMVDELLAFSNRIKSAA
VAADDFSLRWDAILRSFDRSLNFVEGKTSRDIYTRQCSGCGAWLQLRPDWKKCHSCGLLGTEPQTAVTFDPPLTAEEEAL
LYAAWNTAPKYDPSKELKLPTPTRPAA