Solution Structure and Dynamics of an Ultra-Stable Single-Chain Insulin Analog STUDIES OF AN ENGINEERED MONOMER AND IMPLICATIONS FOR RECEPTOR BINDING
Solution structure of an ultra-stable single-chain insulin analog connects protein dynamics to a novel mechanism of receptor binding.
National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Disease (NIH/NIDDK)
National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)
structures with acceptable covalent geometry
TIME AVERAGED NOE RESTRAINED MOLECULAR DYNAMICS; TIME AVERAGING FOR RESIDUES 1-5 AND 28-36 ONLY
1 mM [U-13C; U-15N] Single chain insulin SCI-b, 90% H2O/10% D2O