Receptor binding domain of BoNT/B in complex with mini-protein binder Bot.0671.2

Massively parallel de novo protein design for targeted therapeutics.

GPLGSEILNNIILNLRYKDNNLIDLSGYGAKVEVYDGVELNDKNQFKLTSSANSKIRVTQNQNIIFNSVFLDFSVSFWIR
IPKYKNDGIQNYIHNEYTIINCMKNNSGWKISIRGNRIIWTLIDINGKTKSVFFEYNIREDISEYINRWFFVTITNNLNN
AKIYINGKLESNTDIKDIREVIANGEIIFKLDGDIDRTQFIWMKYFSIFNTELSQSNIEERYKIQSYSEYLKDFWGNPLM
YNKEYYMFNAGNKNSYIKLKKDSPVGEILTRSKYNQNSKYINYRDLYIGEKFIIRRKSNSQSINDDIVRKEDYIYLDFFN
LNQEWRVYTYKYFKKEEEKLFLAPISDSDEFYNTIQIKEYDEQPTYSCQLLFKKDEESTDEIGLIGIHRFYESGIVFEEY
KDYFCISKWYLKEVKRKPYNLKLGCNWQFIPKDEGWTE

chain 'D' and (resid 1090 through 1149 )

chain 'D' and (resid 1150 through 1181 )

chain 'D' and (resid 1182 through 1221 )

chain 'D' and (resid 1222 through 1291 )

chain 'B' and (resid 1028 through 1053 )

chain 'B' and (resid 1054 through 1112 )

chain 'B' and (resid 1113 through 1149 )

chain 'B' and (resid 1150 through 1181 )

chain 'B' and (resid 1182 through 1211 )

chain 'B' and (resid 1212 through 1260 )

chain 'B' and (resid 1261 through 1291 )

chain 'C' and (resid 1028 through 1089 )

chain 'C' and (resid 1090 through 1149 )

chain 'C' and (resid 1150 through 1211 )

chain 'C' and (resid 1212 through 1260 )

chain 'C' and (resid 1261 through 1291 )

chain 'A' and (resid 1028 through 1053 )

chain 'A' and (resid 1054 through 1089 )

chain 'A' and (resid 1090 through 1149 )

chain 'A' and (resid 1150 through 1181 )

chain 'A' and (resid 1182 through 1221 )

chain 'A' and (resid 1222 through 1260 )

chain 'A' and (resid 1261 through 1291 )

chain 'E' and (resid 1090 through 1148 )

chain 'E' and (resid 1149 through 1221 )

chain 'E' and (resid 1222 through 1260 )

chain 'E' and (resid 1261 through 1291 )

EILNNIILNLRYKDNNLIDLSGYGAKVEVYDGVELNDKNQFKLTSSANSKIRVTQNQNIIFNSVFLDFSVSFWIRIPKYK
NDGIQNYIHNEYTIINCMKNNSGWKISIRGNRIIWTLIDINGKTKSVFFEYNIREDISEYINRWFFVTITNNLNNAKIYI
NGKLESNTDIKDIREVIANGEIIFKLDGDIDRTQFIWMKYFSIFNTELSQSNIEERYKIQSYSEYLKDFWGNPLMYNKEY
YMFNAGNKNSYIKLKKDSPVGEILTRSKYNQNSKYINYRDLYIGEKFIIRRKSNSQSINDDIVRKEDYIYLDFFNLNQEW
RVYTYKYFKKEEEKLFLAPISDSDEFYNTIQIKEYDEQPTYSCQLLFKKDEESTDEIGLIGIHRFYESGIVFEEYKDYFC
ISKWYLKEVKRKPYNLKLGCNWQFIPKDEGWTE