Crystal Structure of Mouse Cadherin-23 EC19-21 with non-syndromic deafness (DFNB12) associated mutation R2029W

Zooming in on Cadherin-23: Structural Diversity and Potential Mechanisms of Inherited Deafness.

MNHPLFTEGTYQAEVMENSPAGTPLTVLNGPILALDADEDVYAVVTYQLLGTHSDLFVIDNSTGVVTVRSGIIIDWEAFS
PPFLELLLLAEDIGQLNGTAHLFITILDDNDNWPTFSPPTYTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQ
DRFLIHPVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTII
ANVTAIDLDLNPKLEYHIISIVAKDDTDRLVPDQEDAFAVNINTGSVMVKSPLNRELVATYEVTLSVIDNASDLPEHSVS
VPNAKLTVNILDVNDNLEHHHHHH

0.1 M HEPES pH 7.3
0.1 M CaCl2
27% PEG 400
5% glycerol

National Institutes of Health/National Institute on Deafness and Other Communication Disorders (NIH/NIDCD)

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS

Monomer as determined by Size exclusion chromatography

hearing, mechanotransduction, adhesion, calcium-binding protein, CELL ADHESION

NHPLFTEGTYQAEVMENSPAGTPLTVLNGPILALDADEDVYAVVTYQLLGTHSDLFVIDNSTGVVTVRSGIIIDREAFSP
PFLELLLLAEDIGQLNGTAHLFITILDDNDNWPTFSPPTYTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQD
RFLIHPVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTIIA
NVTAIDLDLNPKLEYHIISIVAKDDTDRLVPDQEDAFAVNINTGSVMVKSPLNRELVATYEVTLSVIDNASDLPEHSVSV
PNAKLTVNILDVNDN