Crystal Structure of Human Protein Phosphatase 5C (PP5C) in complex with a triazole inhibitor

5-phenyl-1H-1,2,3-triazole-4-carboxylic acid

Crystal Structure Human PP5C in Complex with an Inhibitor

GASMTIEDEYSGPKLEDGKVTISFMKELMQWYKDQKKLHRKCAYQILVQVKEVLSKLSTLVETTLKETEKITVCGDTHGQ
FYDLLNIFELNGLPSETNPYIFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLLRGNHETDNMNQIYGFEGEVKAKYTAQ
MYELFSEVFEWLPLAQCINGKVLIMHGGLFSEDGVTLDDIRKIERNRQPPDSGPMCDLLWSDPQPQNGRSISKRGVSCQF
GPDVTKAFLEENNLDYIIRSHEVKAEGYEVAHGGRCVTVFSAPNYCDQMGNKASYIHLQGSDLRPQFHQFTAVPHPNVKP
MAYANTLLQLGMM

20-26% MPD, 4-8% PEG5000MME, 1 mM Manganese chloride, 10 mM Tris

National Institutes of Health/National Institute of Mental Health (NIH/NIMH)

National Institutes of Health/National Institute of Neurological Disorders and Stroke (NIH/NINDS)

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS

Protein Phosphatase, PP5C, Inhibitor Complex, HYSROLASE-HYDROLASE INHIBITOR complex

SMTIEDEYSGPKLEDGKVTISFMKELMQWYKDQKKLHRKCAYQILVQVKEVLSKLSTLVETTLKETEKITVCGDTHGQFY
DLLNIFELNGLPSETNPYIFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLLRGNHETDNMNQIYGFEGEVKAKYTAQMY
ELFSEVFEWLPLAQCINGKVLIMHGGLFSEDGVTLDDIRKIERNRQPPDSGPMCDLLWSDPQPQNGRSISKRGVSCQFGP
DVTKAFLEENNLDYIIRSHEVKAEGYEVAHGGRCVTVFSAPNYCDQMGNKASYIHLQGSDLRPQFHQFTAVPHPNVKPMA
YANTLLQLGMM