Membrane targeting of TIRAP is negatively regulated by phosphorylation in its phosphoinositide-binding motif.
Toll/interleukin-1 receptor domain-containing adapter protein
TIR domain-containing adapter protein,Adaptor protein Wyatt,MyD88 adapter-like protein,MyD88-2
Escherichia coli 'BL21-Gold(DE3)pLysS AG'
National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)
structures with the lowest energy and backbone RMSD < 2A
10 mM d4-sodium citrate (pH 6), 50 mM NaCl, 1 mM NaN3, 10% D2O, and 160 mM d38-DPC.
TIRAP, phosphoinositide, phosphorylation, phosphoinositide-binding motif; structure, SIGNALING PROTEIN