The ER stress sensor PERK luminal domain functions as a molecular chaperone to interact with misfolded proteins.

Eukaryotic translation initiation factor 2-alpha kinase 3

PRKR-like endoplasmic reticulum kinase,Pancreatic eIF2-alpha kinase,HsPEK

ETELRPRGRSLVIISTLDGRIAALDPENHGKKQWDLDVGSGSLVSSSLSKPEVFGNKMIIPSLDGALFQWDQDRESMETV
PFTVESLLESSYKFGDDVVLVGGKSLTTYGLSAYSGKVRYICSALGCRQWDSDEMEQEEDILLLQRTQKTVRAVGPRSGN
EKWNFSVGHFELRYIPDMETRAGFIESTFKPNENTEESKIISDVEEQEAAIMDIVIKVSVADWKVMAFSKKGGHLEWEYQ
FCTPIASAWLLKDGKVIPISLFDDTSYTSNDDVLEDEEDIVEAARGATENSVYLGMYRGQLYLQSSVRISEKFPSSPKAL
ESVTNE

National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)