XChem group deposition -- Crystal Structure of human YEATS4 in complex with XS038644e

Glioma-amplified sequence 41,Gas41,NuMA-binding protein 1,NuBI1

MGVTIVKPIVYGNVARYFGKKREEDGHTHQWTVYVKPYRNEDMSAYVKKIQFKLHESYGNPLRVVTKPPYEITETGWGEF
EIIIKIFFIDPNERPVTLYHLLKLFQSDTNAMLGKKTVVSEFYDEMIFQDPTAMMQQLLTTSRQLTLGAYKHETEFAELE
VKTREKLEAAKKKTAHHHHHH

0.1M tris pH 7.5, 0.15M lithium sulfate, 40% PEG400

human YEATS4 screened against a bromodomain focused fragment Library by X-ray Crystallography at the XChem facility of Diamond Light Source beamline I04-1

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS U VALUES : REFINED INDIVIDUALLY

SGC - Diamond I04-1 fragment screening, PanDDA, XChemExplorer, HISTONE READER, YEATS DOMAIN, TRANSCRIPTION

GVTIVKPIVYGNVARYFGKKREEDGHTHQWTVYVKPYRNEDMSAYVKKIQFKLHESYGNPLRVVTKPPYEITETGWGEFE
IIIKIFFIDPNERPVTLYHLLKLFQSDTNAMLGKKTVVSEFYDEMIFQDPTAMMQQLLTTSRQLTLGAYKHETEFAELEV
KTREKLEAAKKKT