PanDDA analysis group deposition -- Crystal Structure of BRD1 in complex with N10987a

A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density.

BR140-like protein,Bromodomain and PHD finger-containing protein 2

MHHHHHHSSGVDLGTENLYFQSMEQVAMELRLTELTRLLRSVLDQLQDKDPARIFAQPVSLKEVPDYLDHIKHPMDFATM
RKRLEAQGYKNLHEFEEDFDLIIDNCMKYNARDTVFYRAAVRLRDQGGVVLRQARREVDSIGLEEASGMHLPERPA

human BRD1 screened against the 3D-Fragment Consortium Library by X-ray Crystallography at the XChem facility of Diamond Light Source beamline I04-1. Check out the PanDDA event maps at https://zenodo.org/record/290217/files/0_index.html
PanDDA analysis group deposition of models with modelled events (e.g. bound ligands)

PanDDA, SGC - Diamond I04-1 fragment screening, bromodomain, epigenetics, XChemExplorer, GENE REGULATION

VEQVAMELRLTPLTVLLRSVLDQLQDKDPARIFAQPVSLKEVPDYLDHIKHPMDFATMRKRLEAQGYKNLHEFEEDFDLI
IDNCMKYNARDTVFYRAAVRLRDQGGVVLRQARREVDSIGLEEASGMHLPERPA