M. thermoresistible IMPDH in complex with IMP and Compound 31 (AT080)

Fragment-Based Approach to Targeting Inosine-5'-monophosphate Dehydrogenase (IMPDH) from Mycobacterium tuberculosis.

Inosine-5'-monophosphate dehydrogenase,Inosine-5'-monophosphate dehydrogenase

GSSIAERSVPIAVPVPTGGDDPTKIAMLGLTFDDVLLLPAASDVLPANADTSSQLTKKIRLKVPLVSSAMDTVTEARMAI
AMARAGGMGVLHRNLPVAEQAAQVETVKRSGGLLVGAAVGVGDDAWERAMALRDAGVDVLVVDTAHAHNRKVLDMVHRLK
TTVGDEIEVVGGNVATRAAAAALVEAGADAVKVGVGPGSICTTRVVAGVGAPQITAILEAVAACAPHGVPVIADGGLQYS
GDIAKALAAGASTAMLGSLLAGTAESPGELILVNGKQFKSYRGMGSLGAMQGRGGAKSYSKDRYFQDDALSEDKLVPEGI
EGRVPFRGPLSTVIHQLVGGLRAAMGYTGSATIEELQQAQFVQITAAGLKESHPHDITMTVEAPNYYAR

Mycobacterium thermoresistibile (strain ATCC 19527 / DSM 44167 / CIP 105390 / JCM 6362 / NCTC 10409 / 316)

100mM sodium acetate pH 5.5, 200mM calcium chloride, 8-14% iso-propanol

Complex, Fragment, IMPDH, OXIDOREDUCTASE

SIAERSVPIAVPVPTGGDDPTKIAMLGLTFDDVLLLPAASDVLPANADTSSQLTKKIRLKVPLVSSAMDTVTEARMAIAM
ARAGGMGVLHRNLPVAEQAAQVETVKRS

LLVGAAVGVGDDAWERAMALRDAGVDVLVVDTAHAHNRKVLDMVHRLKTTVGDEIEVVGGNVATRAAAAALVEAGADAVK
VGVGPGSICTTRVVAGVGAPQITAILEAVAACAPHGVPVIADGGLQYSGDIAKALAAGASTAMLGSLLAGTAESPGELIL
VNGKQFKSYRGMGSLGAMQGRGGAKSYSKDRYFQDDALSEDKLVPEGIEGRVPFRGPLSTVIHQLVGGLRAAMGYTGSAT
IEELQQAQFVQITAAGLKESHPHDITMTVEAPNYYAR