InhA (T2A mutant) complexed with 2,6-dimethyl-3-phenylpyridin-4(1H)-one

Screening of a Novel Fragment Library with Functional Complexity against Mycobacterium tuberculosis InhA.

Enoyl-[acyl-carrier-protein] reductase [NADH]

Enoyl-ACP reductase,FAS-II enoyl-ACP reductase,NADH-dependent 2-trans-enoyl-ACP reductase

MAGLLDGKRILVSGIITDSSIAFHIARVAQEQGAQLVLTGFDRLRLIQRITDRLPAKAPLLELDVQNEEHLASLAGRVTE
AIGAGNKLDGVVHSIGFMPQTGMGINPFFDAPYADVSKGIHISAYSYASMAKALLPIMNPGGSIVGMDFDPSRAMPAYNW
MTVAKSALESVNRFVAREAGKYGVRSNLVAAGPIRTLAMSAIVGGALGEEAGAQIQLLEEGWDQRAPIGWNMKDATPVAK
TVCALLSDWLPATTGDIIYADGGAHTQLL

0.5M NaCl, 0.1M NaH2PO4 pH 6.8, 15% w/v PEG2K. Cryo - well + 20% glycerol

Inhibitor, complex, fragment based drug discovery, tuberculosis, OXIDOREDUCTASE

GLLDGKRILVSGIITDSSIAFHIARVAQEQGAQLVLTGFDRLRLIQRITDRLPAKAPLLELDVQNEEHLASLAGRVTEAI
GAGNKLDGVVHSIGFMPQTGMGINPFFDAPYADVSKGIHISAYSYASMAKALLPIMNPGGSIVGMDFDPSRAMPAYNWMT
VAKSALESVNRFVAREAGKYGVRSNLVAAGPIRTLAMSAIVGGALGEEAGAQIQLLEEGWDQRAPIGWNMKDATPVAKTV
CALLSDWLPATTGDIIYADGGAHTQLL