BIRC4 RING in complex with dimeric ubiquitin variant

A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants.

A variant of ubiquitin identified from a phage-display library

Baculoviral IAP repeat-containing protein 4,IAP-like protein,hILP,Inhibitor of apoptosis protein 3,hIAP3,RING-type E3 ubiquitin transferase XIAP,X-linked inhibitor of apoptosis protein,X-linked IAP

0.1 M NaHEPES pH 7.5, 1.4 M tri-Na citrate

This RING ligase works as a dimer, and has been well established in literature.

This dimerisation is necessary for the binding and the stimulation effect

E3 ring ligase, ubiquitin variant, LIGASE