Crystal structure of vancomycin-Zn(II) complex
(2S)-amino(3,5-dihydroxyphenyl)ethanoic acid
(2R)-amino(4-hydroxyphenyl)ethanoic acid
Zn(II) mediates vancomycin polymerization and potentiates its antibiotic activity against resistant bacteria.
0.2 M magnesium formate salt, 20% (w/v) PEG 3350
VANCOMYCIN IS A TRICYCLIC GLYCOPEPTIDE. THE SCAFFOLD IS A HEPTAPEPTIDE WITH THE CONFIGURATION D-D-L-D-D-L-L. IT IS FURTHER GLYCOSYLATED BY A DISACCHARIDE MADE OF D-GLUCOSE AND VANCOSAMINE. HERE, VANCOMYCIN IS REPRESENTED BY GROUPING TOUGHER THE SEQUENCE (SEQRES) AND THE TWO LIGANDS (HET) BGC AND RER.
VANCOMYCIN IS A TRICYCLIC GLYCOPEPTIDE, GLYCOSYLATED BY A DISACCHARIDE (RESIDUES 8 AND 9) ON RESIDUE 4.
HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS U VALUES : REFINED INDIVIDUALLY
vancomycin, zinc, glycopeptide, antibiotic