Structure of C-terminal domain from S. cerevisiae Pat1 decapping activator bound to Dcp2 HLM10 peptide (region 954-970)

A unique surface on Pat1 C-terminal domain directly interacts with Dcp2 decapping enzyme and Xrn1 5'-3' mRNA exonuclease in yeast.

DNA topoisomerase 2-associated protein PAT1

Decapping activator and translational repressor PAT1,Topoisomerase II-associated protein PAT1,mRNA turnover protein 1

MHHHHHHSSGSSSTGSSAAAVASKQRRRSSYAFNNGNGATNLNKSGGKKFILELIETVYEEILDLEANLRNGQQTDSTAM
WEALHIDDSSYDVNPFISMLSFDKGIKIMPRIFNFLDKQQKLKILQKIFNELSHLQIIILSSYKTTPKPTLTQLKKVDLF
QMIILKIIVSFLSNNSNFIEIMGLLLQLIRNNNVSFLTTSKIGLNLITILISRAALIKQDSSRSNILSSPEISTWNEIYD
KLFTSLESKIQLIFPPREYNDHIMRLQNDKFMDEAYIWAFLASLAASGKLNHQRIIIDEVRDEIFATINEAETLQKKEKE
LSVLPQRSQELDTELKSIIYNKEKLYQDLNLFLNVMGLVYRDGEISELK

Protein peptide complex, ISOMERASE, rna binding protein

SSGSSSTGSSAAAVASKQRRRSSYAFNNGNGATNLNKSGGKKFILELIETVYEEILDLEANLRNGQQTDSTAMWEALHID
DSSYDVNPFISMLSFDKGIKIMPRIFNFLDKQQKLKILQKIFNELSHLQIIILSSYKTTPKPTLTQLKKVDLFQMIILKI
IVSFLSNNSNFIEIMGLLLQLIRNNNVSFLTTSKIGLNLITILISRAALIKQDSSRSNILSSPEISTWNEIYDKLFTSLE
SKIQLIFPPREYNDHIMRLQNDKFMDEAYIWQFLASLALSGKLNHQRIIIDEVRDEIFATINEAETLQKKEKELSVLPQR
SQELDTELKSIIYNKEKLYQDLNLFLNVMGLVYRDGEISELK