Wilms Tumor Protein (WT1) ZnF2-4 Q369H in complex with formylated DNA

Denys-Drash syndrome associated WT1 glutamine 369 mutants have altered sequence-preferences and altered responses to epigenetic modifications.

DNA (5'-D(*AP*GP*CP*GP*TP*GP*GP*GP*(5FC)P*GP*T)-3')

DNA (5'-D(*TP*AP*(5CM)P*GP*CP*CP*CP*AP*CP*GP*C)-3')

GPLGSEKPYQCDFKDCERRFSRSDHLKRHQRRHTGVKPFQCKTCQRKFSRSDHLKTHTRTHTGEKPFSCRWPSCQKKFAR
SDELVRHHNMHQR

National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)

Wilms Tumor Protein, WT1, zinc finger, 5-formyl cytosine, TRANSCRIPTION-DNA complex

EKPYQCDFKDCERRFSRSDQLKRHQRRHTGVKPFQCKTCQRKFSRSDHLKTHTRTHTGEKPFSCRWPSCQKKFARSDELV
RHHNMHQR

binding site for Di-nucleotide DG E 8 and 5FC E 9

binding site for Di-nucleotide 5FC E 9 and DG E 10

binding site for Di-nucleotide DA F 2 and 5CM F 3

binding site for Di-nucleotide 5CM F 3 and DG F 4