Crystal structure of Cytochrome P450 BM3 heme domain T269V/L272W/L322I/A406S (WIVS) variant with iron(III) deuteroporphyrin IX bound

An Evolved Orthogonal Enzyme/Cofactor Pair.

Bifunctional cytochrome P450/NADPH--P450 reductase

Cytochrome P450(BM-3),Cytochrome P450BM-3,Fatty acid monooxygenase,Flavocytochrome P450 BM3

TIKEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEACDESRFDKNLSQALKFVRD
FAGDGLFTSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNY
RFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDENKRQFQEDIKVMNDLVDKIIADRKASGEQSDDLLTHMLNG
KDPETGEPLDDENIRYQIITFLIAGHETVSGWLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNE
AIRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRAC
IGQQFSLHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAKSKKIPLGGIPSPSTLEHHHHHH

Bacillus megaterium (strain ATCC 14581 / DSM 32 / JCM 2506 / NBRC 15308 / NCIMB 9376 / NCTC 10342 / VKM B-512)

Defense Advanced Research Projects Agency

National Science Foundation (NSF, United States)

P450 BM3, iron(III) deuteroporphyrin IX, OXIDOREDUCTASE

(CHAIN A AND (RESSEQ 4:8 OR (RESID 9 AND
(NAME N OR NAME CA OR NAME C OR NAME O OR
NAME CB )) OR RESSEQ 10:12 OR (RESID 14
AND (NAME N OR NAME CA OR NAME C OR NAME
O OR NAME CB )) OR (RESID 15 AND (NAME N
OR NAME CA OR NAME C OR NAME O OR NAME CB
)) OR RESSEQ 16 OR (RESID 17 AND (NAME N
OR NAME CA OR NAME C OR NAME O OR NAME CB
OR NAME CG )) OR RESSEQ 18:19 OR (RESID
20 AND (NAME N OR NAME CA OR NAME C OR
NAME O OR NAME CB )) OR (RESID 21 AND
(NAME N OR NAME CA OR NAME C OR NAME O OR
NAME CB )) OR RESSEQ 22 OR (RESID 23 AND
(NAME N OR NAME CA OR NAME C OR NAME O OR
NAME CB )) OR RESSEQ 24:30 OR RESSEQ 32:
33 OR (RESID 34 AND (NAME N OR NAME CA OR
NAME C OR NAME O OR NAME CB )) OR RESSEQ
35:40 OR (RESID 41 AND (NAME N OR NAME CA
OR NAME C OR NAME O OR NAME CB )) OR
RESSEQ 42:46 OR (RESID 47 AND (NAME N OR
NAME CA OR NAME C OR NAME O OR NAME CB OR
NAME CG OR NAME CD OR NAME NE )) OR
RESSEQ 48:52 OR (RESID 53 AND (NAME N OR
NAME CA OR NAME C OR NAME O OR NAME CB ))
OR RESSEQ 54:58 OR (RESID 59 AND (NAME N
OR NAME CA OR NAME C OR NAME O OR NAME CB
)) OR RESSEQ 60:91 OR RESSEQ 93 OR RESSEQ
95 OR RESSEQ 98:100 OR (RESID 101 AND
(NAME N OR NAME CA OR NAME C OR NAME O OR
NAME CB OR NAME CG OR NAME ND2)) OR
RESSEQ 102:107 OR (RESID 108 AND (NAME N
OR NAME CA OR NAME C OR NAME O OR NAME CB
)) OR RESSEQ 110:112 OR (RESID 113 AND
(NAME N OR NAME CA OR NAME C OR NAME O OR
NAME CB )) OR RESSEQ 114:166 OR RESSEQ
169:170 OR RESSEQ 172:173 OR (RESID 174
AND (NAME N OR NAME CA OR NAME C OR NAME
O OR NAME CB )) OR (RESID 175 AND (NAME N
OR NAME CA OR NAME C OR NAME O OR NAME CB
OR NAME OG1)) OR RESSEQ 176:181 OR (RESID
182 AND (NAME N OR NAME CA OR NAME C OR
NAME O OR NAME CB )) OR RESSEQ 183:188 OR
RESSEQ 190:191 OR RESSEQ 193:194 OR
(RESID 195 AND (NAME N OR NAME CA OR NAME
C OR NAME O OR NAME CB )) OR RESSEQ 196:
198 OR (RESID 199 AND (NAME N OR NAME CA
OR NAME C OR NAME O OR NAME CB )) OR
(RESID 200 AND (NAME N OR NAME CA OR NAME
C OR NAME O OR NAME CB )) OR RESSEQ 201
OR RESSEQ 204:212 OR (RESID 213 AND (NAME
N OR NAME CA OR NAME C OR NAME O OR NAME
CB )) OR RESSEQ 214 OR RESSEQ 216:217 OR
(RESID 218 AND (NAME N OR NAME CA OR NAME
C OR NAME O OR NAME CB )) OR RESSEQ 219:
223 OR RESSEQ 230:238 OR (RESID 239 AND
(NAME N OR NAME CA OR NAME C OR NAME O OR
NAME CB )) OR RESSEQ 240 OR (RESID 242
AND (NAME N OR NAME CA OR NAME C OR NAME
O OR NAME CB )) OR RESSEQ 243:244 OR
(RESID 245 AND (NAME N OR NAME CA OR NAME
C OR NAME O OR NAME CB )) OR RESSEQ 246
OR RESSEQ 248:249 OR (RESID 250 AND (NAME
N OR NAME CA OR NAME C OR NAME O OR NAME
CB )) OR (RESID 251 AND (NAME N OR NAME
CA OR NAME C OR NAME O OR NAME CB )) OR
RESSEQ 253:254 OR RESSEQ 256:287 OR
(RESID 288 AND (NAME N OR NAME CA OR NAME
C OR NAME O OR NAME CB )) OR RESSEQ 289:
291 OR RESSEQ 293:299 OR (RESID 300 AND
(NAME N OR NAME CA OR NAME C OR NAME O OR
NAME CB )) OR RESSEQ 301 OR (RESID 302
AND (NAME N OR NAME CA OR NAME C OR NAME
O OR NAME CB )) OR RESSEQ 303:308 OR
(RESID 309 AND (NAME N OR NAME CA OR NAME
C OR NAME O OR NAME CB )) OR (RESID 310
AND (NAME N OR NAME CA OR NAME C OR NAME
O OR NAME CB )) OR RESSEQ 311 OR RESSEQ
313:336 OR (RESID 337 AND (NAME N OR NAME
CA OR NAME C OR NAME O OR NAME CB )) OR
RESSEQ 338:343 OR (RESID 344 AND (NAME N
OR NAME CA OR NAME C OR NAME O OR NAME CB
)) OR RESSEQ 345:347 OR (RESID 348 AND
(NAME N OR NAME CA OR NAME C OR NAME O OR
NAME CB )) OR (RESID 349 AND (NAME N OR
NAME CA OR NAME C OR NAME O OR NAME CB ))
OR RESSEQ 350 OR (RESID 351 AND (NAME N
OR NAME CA OR NAME C OR NAME O OR NAME CB
)) OR (RESID 352 AND (NAME N OR NAME CA
OR NAME C OR NAME O OR NAME CB OR NAME CG
OR NAME CD )) OR RESSEQ 353:363 OR RESSEQ
365:368 OR RESSEQ 370:374 OR (RESID 375
AND (NAME N OR NAME CA OR NAME C OR NAME
O OR NAME CB )) OR RESSEQ 376 OR (RESID
377 AND (NAME N OR NAME CA OR NAME C OR
NAME O OR NAME CB )) OR RESSEQ 378:379 OR
(RESID 381 AND (NAME N OR NAME CA OR NAME
C OR NAME O OR NAME CB )) OR RESSEQ 382
OR (RESID 383 AND (NAME N OR NAME CA OR
NAME C OR NAME O OR NAME CB )) OR RESSEQ
384 OR RESSEQ 386 OR RESSEQ 388:390 OR
(RESID 391 AND (NAME N OR NAME CA OR NAME
C OR NAME O OR NAME CB OR NAME CG OR NAME
CD )) OR RESSEQ 392:403 OR RESSEQ 405:418
OR (RESID 419 AND (NAME N OR NAME CA OR
NAME C OR NAME O OR NAME CB OR NAME CG OR
NAME CD )) OR RESSEQ 420:423 OR (RESID
424 AND (NAME N OR NAME CA OR NAME C OR
NAME O OR NAME CB )) OR RESSEQ 425:429 OR
(RESID 430 AND (NAME N OR NAME CA OR NAME
C OR NAME O OR NAME CB )) OR RESSEQ 431:
433 OR (RESID 434 AND (NAME N OR NAME CA
OR NAME C OR NAME O OR NAME CB )) OR
RESSEQ 435:439 OR (RESID 440 AND (NAME N
OR NAME CA OR NAME C OR NAME O OR NAME CB
OR NAME CG OR NAME CD )) OR RESSEQ 441 OR
(RESID 442 AND (NAME N OR NAME CA OR NAME
C OR NAME O OR NAME CB )) OR RESSEQ 443:
450 OR (RESID 451 AND (NAME N OR NAME CA
OR NAME C OR NAME O OR NAME CB OR NAME CG
OR NAME CD )) OR (RESID 452 AND (NAME N
OR NAME CA OR NAME C OR NAME O OR NAME CB
)) OR RESSEQ 453:455))

(CHAIN B AND ((RESID 4 AND (NAME N OR
NAME CA OR NAME C OR NAME O OR NAME CB ))
OR RESSEQ 5:8 OR (RESID 9 AND (NAME N OR
NAME CA OR NAME C OR NAME O OR NAME CB ))
OR RESSEQ 10:12 OR (RESID 14 AND (NAME N
OR NAME CA OR NAME C OR NAME O OR NAME CB
)) OR RESSEQ 15:16 OR (RESID 17 AND (NAME
N OR NAME CA OR NAME C OR NAME O OR NAME
CB OR NAME CG )) OR RESSEQ 18:19 OR
(RESID 20 AND (NAME N OR NAME CA OR NAME
C OR NAME O OR NAME CB )) OR (RESID 21
AND (NAME N OR NAME CA OR NAME C OR NAME
O OR NAME CB )) OR RESSEQ 22:30 OR RESSEQ
32:33 OR (RESID 34 AND (NAME N OR NAME CA
OR NAME C OR NAME O OR NAME CB )) OR
RESSEQ 35:40 OR (RESID 41 AND (NAME N OR
NAME CA OR NAME C OR NAME O OR NAME CB ))
OR RESSEQ 42:46 OR (RESID 47 AND (NAME N
OR NAME CA OR NAME C OR NAME O OR NAME CB
OR NAME CG OR NAME CD OR NAME NE )) OR
RESSEQ 48:52 OR (RESID 53 AND (NAME N OR
NAME CA OR NAME C OR NAME O OR NAME CB ))
OR RESSEQ 54:58 OR (RESID 59 AND (NAME N
OR NAME CA OR NAME C OR NAME O OR NAME CB
)) OR RESSEQ 60:91 OR RESSEQ 93 OR RESSEQ
95 OR RESSEQ 98:100 OR (RESID 101 AND
(NAME N OR NAME CA OR NAME C OR NAME O OR
NAME CB OR NAME CG OR NAME ND2)) OR
RESSEQ 102:107 OR (RESID 108 AND (NAME N
OR NAME CA OR NAME C OR NAME O OR NAME CB
)) OR RESSEQ 110:112 OR (RESID 113 AND
(NAME N OR NAME CA OR NAME C OR NAME O OR
NAME CB )) OR RESSEQ 114:135 OR (RESID
136 AND (NAME N OR NAME CA OR NAME C OR
NAME O OR NAME CB )) OR RESSEQ 137:166 OR
(RESID 169 AND (NAME N OR NAME CA OR NAME
C OR NAME O OR NAME CB )) OR RESSEQ 170
OR RESSEQ 172:173 OR (RESID 174 AND (NAME
N OR NAME CA OR NAME C OR NAME O OR NAME
CB )) OR (RESID 175 AND (NAME N OR NAME
CA OR NAME C OR NAME O OR NAME CB OR NAME
OG1)) OR RESSEQ 176:181 OR (RESID 182 AND
(NAME N OR NAME CA OR NAME C OR NAME O OR
NAME CB )) OR RESSEQ 183:188 OR RESSEQ
190:191 OR RESSEQ 193 OR (RESID 194 AND
(NAME N OR NAME CA OR NAME C OR NAME O OR
NAME CB )) OR (RESID 195 AND (NAME N OR
NAME CA OR NAME C OR NAME O OR NAME CB ))
OR RESSEQ 196:198 OR (RESID 199 AND (NAME
N OR NAME CA OR NAME C OR NAME O OR NAME
CB )) OR RESSEQ 200:201 OR (RESID 204 AND
(NAME N OR NAME CA OR NAME C OR NAME O OR
NAME CB )) OR RESSEQ 205:212 OR (RESID
213 AND (NAME N OR NAME CA OR NAME C OR
NAME O OR NAME CB )) OR (RESID 214 AND
(NAME N OR NAME CA OR NAME C OR NAME O OR
NAME CB )) OR RESSEQ 216:217 OR (RESID
218 AND (NAME N OR NAME CA OR NAME C OR
NAME O OR NAME CB )) OR RESSEQ 219:221 OR
(RESID 222 AND (NAME N OR NAME CA OR NAME
C OR NAME O OR NAME CB )) OR RESSEQ 223
OR RESSEQ 230:238 OR (RESID 239 AND (NAME
N OR NAME CA OR NAME C OR NAME O OR NAME
CB )) OR RESSEQ 240 OR (RESID 242 AND
(NAME N OR NAME CA OR NAME C OR NAME O OR
NAME CB )) OR RESSEQ 243 OR (RESID 244
AND (NAME N OR NAME CA OR NAME C OR NAME
O OR NAME CB )) OR (RESID 245 AND (NAME N
OR NAME CA OR NAME C OR NAME O OR NAME CB
)) OR RESSEQ 246 OR RESSEQ 248:249 OR
(RESID 250 AND (NAME N OR NAME CA OR NAME
C OR NAME O OR NAME CB )) OR (RESID 251
AND (NAME N OR NAME CA OR NAME C OR NAME
O OR NAME CB )) OR RESSEQ 253:254 OR
RESSEQ 256:287 OR (RESID 288 AND (NAME N
OR NAME CA OR NAME C OR NAME O OR NAME CB
)) OR (RESID 289 AND (NAME N OR NAME CA
OR NAME C OR NAME O OR NAME CB )) OR
RESSEQ 290:291 OR RESSEQ 293:299 OR
(RESID 300 AND (NAME N OR NAME CA OR NAME
C OR NAME O OR NAME CB )) OR RESSEQ 301
OR (RESID 302 AND (NAME N OR NAME CA OR
NAME C OR NAME O OR NAME CB )) OR RESSEQ
303:309 OR (RESID 310 AND (NAME N OR NAME
CA OR NAME C OR NAME O OR NAME CB )) OR
RESSEQ 311 OR RESSEQ 313:336 OR (RESID
337 AND (NAME N OR NAME CA OR NAME C OR
NAME O OR NAME CB )) OR RESSEQ 338:343 OR
(RESID 344 AND (NAME N OR NAME CA OR NAME
C OR NAME O OR NAME CB )) OR RESSEQ 345:
348 OR (RESID 349 AND (NAME N OR NAME CA
OR NAME C OR NAME O OR NAME CB )) OR
RESSEQ 350 OR (RESID 351 AND (NAME N OR
NAME CA OR NAME C OR NAME O OR NAME CB ))
OR (RESID 352 AND (NAME N OR NAME CA OR
NAME C OR NAME O OR NAME CB OR NAME CG OR
NAME CD )) OR RESSEQ 353:363 OR RESSEQ
365:368 OR RESSEQ 370:372 OR (RESID 373
AND (NAME N OR NAME CA OR NAME C OR NAME
O OR NAME CB )) OR RESSEQ 374 OR (RESID
375 AND (NAME N OR NAME CA OR NAME C OR
NAME O OR NAME CB )) OR RESSEQ 376 OR
(RESID 377 AND (NAME N OR NAME CA OR NAME
C OR NAME O OR NAME CB )) OR RESSEQ 378:
379 OR (RESID 381 AND (NAME N OR NAME CA
OR NAME C OR NAME O OR NAME CB )) OR
RESSEQ 382 OR (RESID 383 AND (NAME N OR
NAME CA OR NAME C OR NAME O OR NAME CB ))
OR RESSEQ 384 OR RESSEQ 386 OR RESSEQ 388:
390 OR (RESID 391 AND (NAME N OR NAME CA
OR NAME C OR NAME O OR NAME CB OR NAME CG
OR NAME CD )) OR RESSEQ 392:403 OR RESSEQ
405:418 OR (RESID 419 AND (NAME N OR NAME
CA OR NAME C OR NAME O OR NAME CB OR NAME
CG OR NAME CD )) OR RESSEQ 420:423 OR
(RESID 424 AND (NAME N OR NAME CA OR NAME
C OR NAME O OR NAME CB )) OR RESSEQ 425:
429 OR (RESID 430 AND (NAME N OR NAME CA
OR NAME C OR NAME O OR NAME CB )) OR
RESSEQ 431:433 OR (RESID 434 AND (NAME N
OR NAME CA OR NAME C OR NAME O OR NAME CB
)) OR RESSEQ 435:439 OR (RESID 440 AND
(NAME N OR NAME CA OR NAME C OR NAME O OR
NAME CB OR NAME CG OR NAME CD )) OR
RESSEQ 441 OR (RESID 442 AND (NAME N OR
NAME CA OR NAME C OR NAME O OR NAME CB ))
OR RESSEQ 443:446 OR (RESID 447 AND (NAME
N OR NAME CA OR NAME C OR NAME O OR NAME
CB )) OR RESSEQ 448 OR (RESID 449 AND
(NAME N OR NAME CA OR NAME C OR NAME O OR
NAME CB )) OR RESSEQ 450 OR (RESID 451
AND (NAME N OR NAME CA OR NAME C OR NAME
O OR NAME CB OR NAME CG OR NAME CD )) OR
(RESID 452 AND (NAME N OR NAME CA OR NAME
C OR NAME O OR NAME CB )) OR RESSEQ 453:
455))

(CHAIN C AND (RESSEQ 4:12 OR (RESID 14
AND (NAME N OR NAME CA OR NAME C OR NAME
O OR NAME CB )) OR (RESID 15 AND (NAME N
OR NAME CA OR NAME C OR NAME O OR NAME CB
)) OR RESSEQ 16 OR (RESID 17 AND (NAME N
OR NAME CA OR NAME C OR NAME O OR NAME CB
OR NAME CG )) OR RESSEQ 18:19 OR (RESID
20 AND (NAME N OR NAME CA OR NAME C OR
NAME O OR NAME CB )) OR (RESID 21 AND
(NAME N OR NAME CA OR NAME C OR NAME O OR
NAME CB )) OR RESSEQ 22:30 OR RESSEQ 32:
40 OR (RESID 41 AND (NAME N OR NAME CA OR
NAME C OR NAME O OR NAME CB )) OR RESSEQ
42:46 OR (RESID 47 AND (NAME N OR NAME CA
OR NAME C OR NAME O OR NAME CB OR NAME CG
OR NAME CD OR NAME NE )) OR RESSEQ 48:52
OR (RESID 53 AND (NAME N OR NAME CA OR
NAME C OR NAME O OR NAME CB )) OR RESSEQ
54:58 OR (RESID 59 AND (NAME N OR NAME CA
OR NAME C OR NAME O OR NAME CB )) OR
RESSEQ 60:91 OR RESSEQ 93 OR RESSEQ 95 OR
RESSEQ 98:100 OR (RESID 101 AND (NAME N
OR NAME CA OR NAME C OR NAME O OR NAME CB
OR NAME CG OR NAME ND2)) OR RESSEQ 102:
107 OR (RESID 108 AND (NAME N OR NAME CA
OR NAME C OR NAME O OR NAME CB )) OR
(RESID 110 AND (NAME N OR NAME CA OR NAME
C OR NAME O OR NAME CB )) OR RESSEQ 111:
112 OR (RESID 113 AND (NAME N OR NAME CA
OR NAME C OR NAME O OR NAME CB )) OR
RESSEQ 114:135 OR (RESID 136 AND (NAME N
OR NAME CA OR NAME C OR NAME O OR NAME CB
)) OR RESSEQ 137:166 OR RESSEQ 169:170 OR
RESSEQ 172:173 OR (RESID 174 AND (NAME N
OR NAME CA OR NAME C OR NAME O OR NAME CB
)) OR (RESID 175 AND (NAME N OR NAME CA
OR NAME C OR NAME O OR NAME CB OR NAME
OG1)) OR RESSEQ 176:181 OR (RESID 182 AND
(NAME N OR NAME CA OR NAME C OR NAME O OR
NAME CB )) OR RESSEQ 183:188 OR RESSEQ
190:191 OR RESSEQ 193 OR (RESID 194 AND
(NAME N OR NAME CA OR NAME C OR NAME O OR
NAME CB )) OR (RESID 195 AND (NAME N OR
NAME CA OR NAME C OR NAME O OR NAME CB ))
OR RESSEQ 196:198 OR (RESID 199 AND (NAME
N OR NAME CA OR NAME C OR NAME O OR NAME
CB )) OR RESSEQ 200:201 OR (RESID 204 AND
(NAME N OR NAME CA OR NAME C OR NAME O OR
NAME CB )) OR RESSEQ 205:206 OR (RESID
207 AND (NAME N OR NAME CA OR NAME C OR
NAME O OR NAME CB )) OR RESSEQ 208:212 OR
(RESID 213 AND (NAME N OR NAME CA OR NAME
C OR NAME O OR NAME CB )) OR RESSEQ 214
OR RESSEQ 216:221 OR (RESID 222 AND (NAME
N OR NAME CA OR NAME C OR NAME O OR NAME
CB )) OR RESSEQ 223 OR RESSEQ 230:240 OR
(RESID 242 AND (NAME N OR NAME CA OR NAME
C OR NAME O OR NAME CB )) OR RESSEQ 243
OR (RESID 244 AND (NAME N OR NAME CA OR
NAME C OR NAME O OR NAME CB )) OR (RESID
245 AND (NAME N OR NAME CA OR NAME C OR
NAME O OR NAME CB )) OR RESSEQ 246 OR
RESSEQ 248:249 OR (RESID 250 AND (NAME N
OR NAME CA OR NAME C OR NAME O OR NAME CB
)) OR (RESID 251 AND (NAME N OR NAME CA
OR NAME C OR NAME O OR NAME CB )) OR
RESSEQ 253:254 OR RESSEQ 256:287 OR
(RESID 288 AND (NAME N OR NAME CA OR NAME
C OR NAME O OR NAME CB )) OR (RESID 289
AND (NAME N OR NAME CA OR NAME C OR NAME
O OR NAME CB )) OR RESSEQ 290:291 OR
RESSEQ 293:301 OR (RESID 302 AND (NAME N
OR NAME CA OR NAME C OR NAME O OR NAME CB
)) OR RESSEQ 303:308 OR (RESID 309 AND
(NAME N OR NAME CA OR NAME C OR NAME O OR
NAME CB )) OR RESSEQ 310:311 OR RESSEQ
313:336 OR (RESID 337 AND (NAME N OR NAME
CA OR NAME C OR NAME O OR NAME CB )) OR
RESSEQ 338:343 OR (RESID 344 AND (NAME N
OR NAME CA OR NAME C OR NAME O OR NAME CB
)) OR RESSEQ 345:347 OR (RESID 348 AND
(NAME N OR NAME CA OR NAME C OR NAME O OR
NAME CB )) OR (RESID 349 AND (NAME N OR
NAME CA OR NAME C OR NAME O OR NAME CB ))
OR RESSEQ 350 OR (RESID 351 AND (NAME N
OR NAME CA OR NAME C OR NAME O OR NAME CB
)) OR (RESID 352 AND (NAME N OR NAME CA
OR NAME C OR NAME O OR NAME CB OR NAME CG
OR NAME CD )) OR RESSEQ 353:363 OR RESSEQ
365:368 OR RESSEQ 370:374 OR (RESID 375
AND (NAME N OR NAME CA OR NAME C OR NAME
O OR NAME CB )) OR RESSEQ 376 OR (RESID
377 AND (NAME N OR NAME CA OR NAME C OR
NAME O OR NAME CB )) OR RESSEQ 378:379 OR
RESSEQ 381:382 OR (RESID 383 AND (NAME N
OR NAME CA OR NAME C OR NAME O OR NAME CB
)) OR RESSEQ 384 OR RESSEQ 386 OR RESSEQ
388:390 OR (RESID 391 AND (NAME N OR NAME
CA OR NAME C OR NAME O OR NAME CB OR NAME
CG OR NAME CD )) OR RESSEQ 392:403 OR
RESSEQ 405:418 OR (RESID 419 AND (NAME N
OR NAME CA OR NAME C OR NAME O OR NAME CB
OR NAME CG OR NAME CD )) OR RESSEQ 420:
423 OR (RESID 424 AND (NAME N OR NAME CA
OR NAME C OR NAME O OR NAME CB )) OR
RESSEQ 425:429 OR (RESID 430 AND (NAME N
OR NAME CA OR NAME C OR NAME O OR NAME CB
)) OR RESSEQ 431:433 OR (RESID 434 AND
(NAME N OR NAME CA OR NAME C OR NAME O OR
NAME CB )) OR RESSEQ 435:439 OR (RESID
440 AND (NAME N OR NAME CA OR NAME C OR
NAME O OR NAME CB OR NAME CG OR NAME CD ))
OR RESSEQ 441 OR (RESID 442 AND (NAME N
OR NAME CA OR NAME C OR NAME O OR NAME CB
)) OR RESSEQ 443:446 OR (RESID 447 AND
(NAME N OR NAME CA OR NAME C OR NAME O OR
NAME CB )) OR RESSEQ 448:450 OR (RESID
451 AND (NAME N OR NAME CA OR NAME C OR
NAME O OR NAME CB OR NAME CG OR NAME CD ))
OR (RESID 452 AND (NAME N OR NAME CA OR
NAME C OR NAME O OR NAME CB )) OR RESSEQ
453:455))

(CHAIN D AND ((RESID 4 AND (NAME N OR
NAME CA OR NAME C OR NAME O OR NAME CB ))
OR RESSEQ 5:12 OR RESSEQ 14:22 OR (RESID
23 AND (NAME N OR NAME CA OR NAME C OR
NAME O OR NAME CB )) OR RESSEQ 24:30 OR
RESSEQ 32:33 OR (RESID 34 AND (NAME N OR
NAME CA OR NAME C OR NAME O OR NAME CB ))
OR RESSEQ 35:52 OR (RESID 53 AND (NAME N
OR NAME CA OR NAME C OR NAME O OR NAME CB
)) OR RESSEQ 54:58 OR (RESID 59 AND (NAME
N OR NAME CA OR NAME C OR NAME O OR NAME
CB )) OR RESSEQ 60:91 OR RESSEQ 93 OR
RESSEQ 95 OR RESSEQ 98:100 OR (RESID 101
AND (NAME N OR NAME CA OR NAME C OR NAME
O OR NAME CB OR NAME CG OR NAME ND2)) OR
RESSEQ 102:108 OR RESSEQ 110:112 OR
(RESID 113 AND (NAME N OR NAME CA OR NAME
C OR NAME O OR NAME CB )) OR RESSEQ 114:
135 OR (RESID 136 AND (NAME N OR NAME CA
OR NAME C OR NAME O OR NAME CB )) OR
RESSEQ 137:166 OR RESSEQ 169:170 OR
RESSEQ 172:173 OR (RESID 174 AND (NAME N
OR NAME CA OR NAME C OR NAME O OR NAME CB
)) OR (RESID 175 AND (NAME N OR NAME CA
OR NAME C OR NAME O OR NAME CB OR NAME
OG1)) OR RESSEQ 176:188 OR RESSEQ 190:191
OR RESSEQ 193:194 OR (RESID 195 AND (NAME
N OR NAME CA OR NAME C OR NAME O OR NAME
CB )) OR RESSEQ 196:198 OR (RESID 199 AND
(NAME N OR NAME CA OR NAME C OR NAME O OR
NAME CB )) OR (RESID 200 AND (NAME N OR
NAME CA OR NAME C OR NAME O OR NAME CB ))
OR RESSEQ 201 OR (RESID 204 AND (NAME N
OR NAME CA OR NAME C OR NAME O OR NAME CB
)) OR RESSEQ 205:212 OR (RESID 213 AND
(NAME N OR NAME CA OR NAME C OR NAME O OR
NAME CB )) OR RESSEQ 214 OR RESSEQ 216 OR
(RESID 217 AND (NAME N OR NAME CA OR NAME
C OR NAME O OR NAME CB )) OR RESSEQ 218:
223 OR RESSEQ 230:238 OR (RESID 239 AND
(NAME N OR NAME CA OR NAME C OR NAME O OR
NAME CB )) OR RESSEQ 240 OR (RESID 242
AND (NAME N OR NAME CA OR NAME C OR NAME
O OR NAME CB )) OR RESSEQ 243:246 OR
RESSEQ 248:249 OR (RESID 250 AND (NAME N
OR NAME CA OR NAME C OR NAME O OR NAME CB
)) OR RESSEQ 251 OR RESSEQ 253:254 OR
RESSEQ 256:291 OR RESSEQ 293:299 OR
(RESID 300 AND (NAME N OR NAME CA OR NAME
C OR NAME O OR NAME CB )) OR RESSEQ 301
OR (RESID 302 AND (NAME N OR NAME CA OR
NAME C OR NAME O OR NAME CB )) OR RESSEQ
303:311 OR RESSEQ 313:336 OR (RESID 337
AND (NAME N OR NAME CA OR NAME C OR NAME
O OR NAME CB )) OR RESSEQ 338:347 OR
(RESID 348 AND (NAME N OR NAME CA OR NAME
C OR NAME O OR NAME CB )) OR (RESID 349
AND (NAME N OR NAME CA OR NAME C OR NAME
O OR NAME CB )) OR RESSEQ 350 OR (RESID
351 AND (NAME N OR NAME CA OR NAME C OR
NAME O OR NAME CB )) OR (RESID 352 AND
(NAME N OR NAME CA OR NAME C OR NAME O OR
NAME CB OR NAME CG OR NAME CD )) OR
RESSEQ 353:363 OR RESSEQ 365:368 OR
RESSEQ 370:372 OR (RESID 373 AND (NAME N
OR NAME CA OR NAME C OR NAME O OR NAME CB
)) OR RESSEQ 374:379 OR RESSEQ 381:384 OR
RESSEQ 386 OR RESSEQ 388:403 OR RESSEQ
405:429 OR (RESID 430 AND (NAME N OR NAME
CA OR NAME C OR NAME O OR NAME CB )) OR
RESSEQ 431:441 OR (RESID 442 AND (NAME N
OR NAME CA OR NAME C OR NAME O OR NAME CB
)) OR RESSEQ 443:446 OR (RESID 447 AND
(NAME N OR NAME CA OR NAME C OR NAME O OR
NAME CB )) OR RESSEQ 448 OR (RESID 449
AND (NAME N OR NAME CA OR NAME C OR NAME
O OR NAME CB )) OR RESSEQ 450:451 OR
(RESID 452 AND (NAME N OR NAME CA OR NAME
C OR NAME O OR NAME CB )) OR RESSEQ 453:
455))

(CHAIN E AND ((RESID 4 AND (NAME N OR
NAME CA OR NAME C OR NAME O OR NAME CB ))
OR RESSEQ 5:8 OR (RESID 9 AND (NAME N OR
NAME CA OR NAME C OR NAME O OR NAME CB ))
OR RESSEQ 10:12 OR (RESID 14 AND (NAME N
OR NAME CA OR NAME C OR NAME O OR NAME CB
)) OR (RESID 15 AND (NAME N OR NAME CA OR
NAME C OR NAME O OR NAME CB )) OR RESSEQ
16 OR (RESID 17 AND (NAME N OR NAME CA OR
NAME C OR NAME O OR NAME CB OR NAME CG ))
OR RESSEQ 18:19 OR (RESID 20 AND (NAME N
OR NAME CA OR NAME C OR NAME O OR NAME CB
)) OR (RESID 21 AND (NAME N OR NAME CA OR
NAME C OR NAME O OR NAME CB )) OR RESSEQ
22 OR (RESID 23 AND (NAME N OR NAME CA OR
NAME C OR NAME O OR NAME CB )) OR RESSEQ
24:30 OR RESSEQ 32:33 OR (RESID 34 AND
(NAME N OR NAME CA OR NAME C OR NAME O OR
NAME CB )) OR RESSEQ 35:40 OR (RESID 41
AND (NAME N OR NAME CA OR NAME C OR NAME
O OR NAME CB )) OR RESSEQ 42:46 OR (RESID
47 AND (NAME N OR NAME CA OR NAME C OR
NAME O OR NAME CB OR NAME CG OR NAME CD
OR NAME NE )) OR RESSEQ 48:52 OR (RESID
53 AND (NAME N OR NAME CA OR NAME C OR
NAME O OR NAME CB )) OR RESSEQ 54:91 OR
RESSEQ 93 OR RESSEQ 95 OR RESSEQ 98:100
OR (RESID 101 AND (NAME N OR NAME CA OR
NAME C OR NAME O OR NAME CB OR NAME CG OR
NAME ND2)) OR RESSEQ 102:107 OR (RESID
108 AND (NAME N OR NAME CA OR NAME C OR
NAME O OR NAME CB )) OR (RESID 110 AND
(NAME N OR NAME CA OR NAME C OR NAME O OR
NAME CB )) OR RESSEQ 111:112 OR (RESID
113 AND (NAME N OR NAME CA OR NAME C OR
NAME O OR NAME CB )) OR RESSEQ 114:135 OR
(RESID 136 AND (NAME N OR NAME CA OR NAME
C OR NAME O OR NAME CB )) OR RESSEQ 137:
166 OR RESSEQ 169:170 OR RESSEQ 172:173
OR (RESID 174 AND (NAME N OR NAME CA OR
NAME C OR NAME O OR NAME CB )) OR (RESID
175 AND (NAME N OR NAME CA OR NAME C OR
NAME O OR NAME CB OR NAME OG1)) OR RESSEQ
176:181 OR (RESID 182 AND (NAME N OR NAME
CA OR NAME C OR NAME O OR NAME CB )) OR
RESSEQ 183:188 OR RESSEQ 190:191 OR
RESSEQ 193:194 OR (RESID 195 AND (NAME N
OR NAME CA OR NAME C OR NAME O OR NAME CB
)) OR RESSEQ 196:198 OR (RESID 199 AND
(NAME N OR NAME CA OR NAME C OR NAME O OR
NAME CB )) OR (RESID 200 AND (NAME N OR
NAME CA OR NAME C OR NAME O OR NAME CB ))
OR RESSEQ 201 OR (RESID 204 AND (NAME N
OR NAME CA OR NAME C OR NAME O OR NAME CB
)) OR RESSEQ 205:206 OR (RESID 207 AND
(NAME N OR NAME CA OR NAME C OR NAME O OR
NAME CB )) OR RESSEQ 208:209 OR (RESID
210 AND (NAME N OR NAME CA OR NAME C OR
NAME O OR NAME CB )) OR RESSEQ 211:212 OR
(RESID 213 AND (NAME N OR NAME CA OR NAME
C OR NAME O OR NAME CB )) OR RESSEQ 214
OR RESSEQ 216 OR (RESID 217 AND (NAME N
OR NAME CA OR NAME C OR NAME O OR NAME CB
)) OR (RESID 218 AND (NAME N OR NAME CA
OR NAME C OR NAME O OR NAME CB )) OR
RESSEQ 219:221 OR (RESID 222 AND (NAME N
OR NAME CA OR NAME C OR NAME O OR NAME CB
)) OR RESSEQ 223 OR RESSEQ 230 OR (RESID
231 AND (NAME N OR NAME CA OR NAME C OR
NAME O OR NAME CB )) OR RESSEQ 232:238 OR
(RESID 239 AND (NAME N OR NAME CA OR NAME
C OR NAME O OR NAME CB )) OR RESSEQ 240
OR (RESID 242 AND (NAME N OR NAME CA OR
NAME C OR NAME O OR NAME CB )) OR RESSEQ
243 OR (RESID 244 AND (NAME N OR NAME CA
OR NAME C OR NAME O OR NAME CB )) OR
(RESID 245 AND (NAME N OR NAME CA OR NAME
C OR NAME O OR NAME CB )) OR RESSEQ 246
OR RESSEQ 248:250 OR (RESID 251 AND (NAME
N OR NAME CA OR NAME C OR NAME O OR NAME
CB )) OR RESSEQ 253:254 OR RESSEQ 256:287
OR (RESID 288 AND (NAME N OR NAME CA OR
NAME C OR NAME O OR NAME CB )) OR (RESID
289 AND (NAME N OR NAME CA OR NAME C OR
NAME O OR NAME CB )) OR RESSEQ 290:291 OR
RESSEQ 293:299 OR (RESID 300 AND (NAME N
OR NAME CA OR NAME C OR NAME O OR NAME CB
)) OR RESSEQ 301 OR (RESID 302 AND (NAME
N OR NAME CA OR NAME C OR NAME O OR NAME
CB )) OR RESSEQ 303:305 OR (RESID 306 AND
(NAME N OR NAME CA OR NAME C OR NAME O OR
NAME CB )) OR RESSEQ 307:308 OR (RESID
309 AND (NAME N OR NAME CA OR NAME C OR
NAME O OR NAME CB )) OR RESSEQ 310:311 OR
RESSEQ 313:343 OR (RESID 344 AND (NAME N
OR NAME CA OR NAME C OR NAME O OR NAME CB
)) OR RESSEQ 345:347 OR (RESID 348 AND
(NAME N OR NAME CA OR NAME C OR NAME O OR
NAME CB )) OR (RESID 349 AND (NAME N OR
NAME CA OR NAME C OR NAME O OR NAME CB ))
OR RESSEQ 350 OR (RESID 351 AND (NAME N
OR NAME CA OR NAME C OR NAME O OR NAME CB
)) OR (RESID 352 AND (NAME N OR NAME CA
OR NAME C OR NAME O OR NAME CB OR NAME CG
OR NAME CD )) OR RESSEQ 353:363 OR RESSEQ
365:368 OR RESSEQ 370:374 OR (RESID 375
AND (NAME N OR NAME CA OR NAME C OR NAME
O OR NAME CB )) OR RESSEQ 376 OR (RESID
377 AND (NAME N OR NAME CA OR NAME C OR
NAME O OR NAME CB )) OR RESSEQ 378:379 OR
(RESID 381 AND (NAME N OR NAME CA OR NAME
C OR NAME O OR NAME CB )) OR RESSEQ 382:
384 OR RESSEQ 386 OR RESSEQ 388:390 OR
(RESID 391 AND (NAME N OR NAME CA OR NAME
C OR NAME O OR NAME CB OR NAME CG OR NAME
CD )) OR RESSEQ 392:403 OR RESSEQ 405:418
OR (RESID 419 AND (NAME N OR NAME CA OR
NAME C OR NAME O OR NAME CB OR NAME CG OR
NAME CD )) OR RESSEQ 420:423 OR (RESID
424 AND (NAME N OR NAME CA OR NAME C OR
NAME O OR NAME CB )) OR RESSEQ 425:429 OR
(RESID 430 AND (NAME N OR NAME CA OR NAME
C OR NAME O OR NAME CB )) OR RESSEQ 431:
433 OR (RESID 434 AND (NAME N OR NAME CA
OR NAME C OR NAME O OR NAME CB )) OR
RESSEQ 435:439 OR (RESID 440 AND (NAME N
OR NAME CA OR NAME C OR NAME O OR NAME CB
OR NAME CG OR NAME CD )) OR RESSEQ 441 OR
(RESID 442 AND (NAME N OR NAME CA OR NAME
C OR NAME O OR NAME CB )) OR RESSEQ 443:
446 OR (RESID 447 AND (NAME N OR NAME CA
OR NAME C OR NAME O OR NAME CB )) OR
RESSEQ 448 OR (RESID 449 AND (NAME N OR
NAME CA OR NAME C OR NAME O OR NAME CB ))
OR RESSEQ 450 OR (RESID 451 AND (NAME N
OR NAME CA OR NAME C OR NAME O OR NAME CB
OR NAME CG OR NAME CD )) OR RESSEQ 452:
455))

(CHAIN F AND ((RESID 4 AND (NAME N OR
NAME CA OR NAME C OR NAME O OR NAME CB ))
OR RESSEQ 5:8 OR (RESID 9 AND (NAME N OR
NAME CA OR NAME C OR NAME O OR NAME CB ))
OR RESSEQ 10:12 OR (RESID 14 AND (NAME N
OR NAME CA OR NAME C OR NAME O OR NAME CB
)) OR RESSEQ 15:16 OR (RESID 17 AND (NAME
N OR NAME CA OR NAME C OR NAME O OR NAME
CB OR NAME CG )) OR RESSEQ 18:19 OR
(RESID 20 AND (NAME N OR NAME CA OR NAME
C OR NAME O OR NAME CB )) OR (RESID 21
AND (NAME N OR NAME CA OR NAME C OR NAME
O OR NAME CB )) OR RESSEQ 22 OR (RESID 23
AND (NAME N OR NAME CA OR NAME C OR NAME
O OR NAME CB )) OR RESSEQ 24:30 OR RESSEQ
32:33 OR (RESID 34 AND (NAME N OR NAME CA
OR NAME C OR NAME O OR NAME CB )) OR
RESSEQ 35:40 OR (RESID 41 AND (NAME N OR
NAME CA OR NAME C OR NAME O OR NAME CB ))
OR RESSEQ 42:46 OR (RESID 47 AND (NAME N
OR NAME CA OR NAME C OR NAME O OR NAME CB
OR NAME CG OR NAME CD OR NAME NE )) OR
RESSEQ 48:91 OR RESSEQ 93 OR RESSEQ 95 OR
RESSEQ 98:100 OR (RESID 101 AND (NAME N
OR NAME CA OR NAME C OR NAME O OR NAME CB
OR NAME CG OR NAME ND2)) OR RESSEQ 102:
107 OR (RESID 108 AND (NAME N OR NAME CA
OR NAME C OR NAME O OR NAME CB )) OR
RESSEQ 110:112 OR (RESID 113 AND (NAME N
OR NAME CA OR NAME C OR NAME O OR NAME CB
)) OR RESSEQ 114:135 OR (RESID 136 AND
(NAME N OR NAME CA OR NAME C OR NAME O OR
NAME CB )) OR RESSEQ 137:166 OR (RESID
169 AND (NAME N OR NAME CA OR NAME C OR
NAME O OR NAME CB )) OR RESSEQ 170 OR
RESSEQ 172:173 OR (RESID 174 AND (NAME N
OR NAME CA OR NAME C OR NAME O OR NAME CB
)) OR (RESID 175 AND (NAME N OR NAME CA
OR NAME C OR NAME O OR NAME CB OR NAME
OG1)) OR RESSEQ 176:181 OR (RESID 182 AND
(NAME N OR NAME CA OR NAME C OR NAME O OR
NAME CB )) OR RESSEQ 183:188 OR RESSEQ
190:191 OR RESSEQ 193:199 OR (RESID 200
AND (NAME N OR NAME CA OR NAME C OR NAME
O OR NAME CB )) OR RESSEQ 201 OR (RESID
204 AND (NAME N OR NAME CA OR NAME C OR
NAME O OR NAME CB )) OR RESSEQ 205:209 OR
(RESID 210 AND (NAME N OR NAME CA OR NAME
C OR NAME O OR NAME CB )) OR RESSEQ 211:
212 OR (RESID 213 AND (NAME N OR NAME CA
OR NAME C OR NAME O OR NAME CB )) OR
(RESID 214 AND (NAME N OR NAME CA OR NAME
C OR NAME O OR NAME CB )) OR RESSEQ 216
OR (RESID 217 AND (NAME N OR NAME CA OR
NAME C OR NAME O OR NAME CB )) OR (RESID
218 AND (NAME N OR NAME CA OR NAME C OR
NAME O OR NAME CB )) OR RESSEQ 219:221 OR
(RESID 222 AND (NAME N OR NAME CA OR NAME
C OR NAME O OR NAME CB )) OR RESSEQ 223
OR RESSEQ 230:238 OR (RESID 239 AND (NAME
N OR NAME CA OR NAME C OR NAME O OR NAME
CB )) OR RESSEQ 240 OR (RESID 242 AND
(NAME N OR NAME CA OR NAME C OR NAME O OR
NAME CB )) OR RESSEQ 243:244 OR (RESID
245 AND (NAME N OR NAME CA OR NAME C OR
NAME O OR NAME CB )) OR RESSEQ 246 OR
RESSEQ 248:249 OR (RESID 250 AND (NAME N
OR NAME CA OR NAME C OR NAME O OR NAME CB
)) OR (RESID 251 AND (NAME N OR NAME CA
OR NAME C OR NAME O OR NAME CB )) OR
RESSEQ 253:254 OR RESSEQ 256:287 OR
(RESID 288 AND (NAME N OR NAME CA OR NAME
C OR NAME O OR NAME CB )) OR (RESID 289
AND (NAME N OR NAME CA OR NAME C OR NAME
O OR NAME CB )) OR RESSEQ 290:291 OR
RESSEQ 293:299 OR (RESID 300 AND (NAME N
OR NAME CA OR NAME C OR NAME O OR NAME CB
)) OR RESSEQ 301 OR (RESID 302 AND (NAME
N OR NAME CA OR NAME C OR NAME O OR NAME
CB )) OR RESSEQ 303:308 OR (RESID 309 AND
(NAME N OR NAME CA OR NAME C OR NAME O OR
NAME CB )) OR (RESID 310 AND (NAME N OR
NAME CA OR NAME C OR NAME O OR NAME CB ))
OR RESSEQ 311 OR RESSEQ 313:336 OR (RESID
337 AND (NAME N OR NAME CA OR NAME C OR
NAME O OR NAME CB )) OR RESSEQ 338:363 OR
RESSEQ 365:368 OR RESSEQ 370:374 OR
(RESID 375 AND (NAME N OR NAME CA OR NAME
C OR NAME O OR NAME CB )) OR RESSEQ 376
OR (RESID 377 AND (NAME N OR NAME CA OR
NAME C OR NAME O OR NAME CB )) OR RESSEQ
378:379 OR (RESID 381 AND (NAME N OR NAME
CA OR NAME C OR NAME O OR NAME CB )) OR
RESSEQ 382 OR (RESID 383 AND (NAME N OR
NAME CA OR NAME C OR NAME O OR NAME CB ))
OR RESSEQ 384 OR RESSEQ 386 OR RESSEQ 388:
390 OR (RESID 391 AND (NAME N OR NAME CA
OR NAME C OR NAME O OR NAME CB OR NAME CG
OR NAME CD )) OR RESSEQ 392:403 OR RESSEQ
405:418 OR (RESID 419 AND (NAME N OR NAME
CA OR NAME C OR NAME O OR NAME CB OR NAME
CG OR NAME CD )) OR RESSEQ 420:423 OR
(RESID 424 AND (NAME N OR NAME CA OR NAME
C OR NAME O OR NAME CB )) OR RESSEQ 425:
433 OR (RESID 434 AND (NAME N OR NAME CA
OR NAME C OR NAME O OR NAME CB )) OR
RESSEQ 435:439 OR (RESID 440 AND (NAME N
OR NAME CA OR NAME C OR NAME O OR NAME CB
OR NAME CG OR NAME CD )) OR RESSEQ 441 OR
(RESID 442 AND (NAME N OR NAME CA OR NAME
C OR NAME O OR NAME CB )) OR RESSEQ 443:
446 OR (RESID 447 AND (NAME N OR NAME CA
OR NAME C OR NAME O OR NAME CB )) OR
RESSEQ 448 OR (RESID 449 AND (NAME N OR
NAME CA OR NAME C OR NAME O OR NAME CB ))
OR RESSEQ 450 OR (RESID 451 AND (NAME N
OR NAME CA OR NAME C OR NAME O OR NAME CB
OR NAME CG OR NAME CD )) OR (RESID 452
AND (NAME N OR NAME CA OR NAME C OR NAME
O OR NAME CB )) OR RESSEQ 453:455))

(CHAIN G AND (RESSEQ 4:12 OR (RESID 14
AND (NAME N OR NAME CA OR NAME C OR NAME
O OR NAME CB )) OR (RESID 15 AND (NAME N
OR NAME CA OR NAME C OR NAME O OR NAME CB
)) OR RESSEQ 16 OR (RESID 17 AND (NAME N
OR NAME CA OR NAME C OR NAME O OR NAME CB
OR NAME CG )) OR RESSEQ 18:19 OR (RESID
20 AND (NAME N OR NAME CA OR NAME C OR
NAME O OR NAME CB )) OR (RESID 21 AND
(NAME N OR NAME CA OR NAME C OR NAME O OR
NAME CB )) OR RESSEQ 22 OR (RESID 23 AND
(NAME N OR NAME CA OR NAME C OR NAME O OR
NAME CB )) OR RESSEQ 24:30 OR RESSEQ 32:
33 OR (RESID 34 AND (NAME N OR NAME CA OR
NAME C OR NAME O OR NAME CB )) OR RESSEQ
35:40 OR (RESID 41 AND (NAME N OR NAME CA
OR NAME C OR NAME O OR NAME CB )) OR
RESSEQ 42:46 OR (RESID 47 AND (NAME N OR
NAME CA OR NAME C OR NAME O OR NAME CB OR
NAME CG OR NAME CD OR NAME NE )) OR
RESSEQ 48:52 OR (RESID 53 AND (NAME N OR
NAME CA OR NAME C OR NAME O OR NAME CB ))
OR RESSEQ 54:58 OR (RESID 59 AND (NAME N
OR NAME CA OR NAME C OR NAME O OR NAME CB
)) OR RESSEQ 60:91 OR RESSEQ 93 OR RESSEQ
95 OR RESSEQ 98:100 OR (RESID 101 AND
(NAME N OR NAME CA OR NAME C OR NAME O OR
NAME CB OR NAME CG OR NAME ND2)) OR
RESSEQ 102:107 OR (RESID 108 AND (NAME N
OR NAME CA OR NAME C OR NAME O OR NAME CB
)) OR (RESID 110 AND (NAME N OR NAME CA
OR NAME C OR NAME O OR NAME CB )) OR
RESSEQ 111:135 OR (RESID 136 AND (NAME N
OR NAME CA OR NAME C OR NAME O OR NAME CB
)) OR RESSEQ 137:166 OR RESSEQ 169:170 OR
RESSEQ 172:174 OR (RESID 175 AND (NAME N
OR NAME CA OR NAME C OR NAME O OR NAME CB
OR NAME OG1)) OR RESSEQ 176:188 OR RESSEQ
190:191 OR RESSEQ 193 OR (RESID 194 AND
(NAME N OR NAME CA OR NAME C OR NAME O OR
NAME CB )) OR (RESID 195 AND (NAME N OR
NAME CA OR NAME C OR NAME O OR NAME CB ))
OR RESSEQ 196:198 OR (RESID 199 AND (NAME
N OR NAME CA OR NAME C OR NAME O OR NAME
CB )) OR (RESID 200 AND (NAME N OR NAME
CA OR NAME C OR NAME O OR NAME CB )) OR
RESSEQ 201 OR (RESID 204 AND (NAME N OR
NAME CA OR NAME C OR NAME O OR NAME CB ))
OR RESSEQ 205:206 OR (RESID 207 AND (NAME
N OR NAME CA OR NAME C OR NAME O OR NAME
CB )) OR RESSEQ 208:214 OR RESSEQ 216 OR
(RESID 217 AND (NAME N OR NAME CA OR NAME
C OR NAME O OR NAME CB )) OR (RESID 218
AND (NAME N OR NAME CA OR NAME C OR NAME
O OR NAME CB )) OR RESSEQ 219:223 OR
RESSEQ 230:238 OR (RESID 239 AND (NAME N
OR NAME CA OR NAME C OR NAME O OR NAME CB
)) OR RESSEQ 240 OR RESSEQ 242:243 OR
(RESID 244 AND (NAME N OR NAME CA OR NAME
C OR NAME O OR NAME CB )) OR (RESID 245
AND (NAME N OR NAME CA OR NAME C OR NAME
O OR NAME CB )) OR RESSEQ 246 OR RESSEQ
248:249 OR (RESID 250 AND (NAME N OR NAME
CA OR NAME C OR NAME O OR NAME CB )) OR
RESSEQ 251 OR RESSEQ 253:254 OR RESSEQ
256:288 OR (RESID 289 AND (NAME N OR NAME
CA OR NAME C OR NAME O OR NAME CB )) OR
RESSEQ 290:291 OR RESSEQ 293:299 OR
(RESID 300 AND (NAME N OR NAME CA OR NAME
C OR NAME O OR NAME CB )) OR RESSEQ 301:
305 OR (RESID 306 AND (NAME N OR NAME CA
OR NAME C OR NAME O OR NAME CB )) OR
RESSEQ 307:308 OR (RESID 309 AND (NAME N
OR NAME CA OR NAME C OR NAME O OR NAME CB
)) OR (RESID 310 AND (NAME N OR NAME CA
OR NAME C OR NAME O OR NAME CB )) OR
RESSEQ 311 OR RESSEQ 313:336 OR (RESID
337 AND (NAME N OR NAME CA OR NAME C OR
NAME O OR NAME CB )) OR RESSEQ 338:343 OR
(RESID 344 AND (NAME N OR NAME CA OR NAME
C OR NAME O OR NAME CB )) OR RESSEQ 345:
347 OR (RESID 348 AND (NAME N OR NAME CA
OR NAME C OR NAME O OR NAME CB )) OR
(RESID 349 AND (NAME N OR NAME CA OR NAME
C OR NAME O OR NAME CB )) OR RESSEQ 350
OR (RESID 351 AND (NAME N OR NAME CA OR
NAME C OR NAME O OR NAME CB )) OR (RESID
352 AND (NAME N OR NAME CA OR NAME C OR
NAME O OR NAME CB OR NAME CG OR NAME CD ))
OR RESSEQ 353:363 OR RESSEQ 365:368 OR
RESSEQ 370:372 OR (RESID 373 AND (NAME N
OR NAME CA OR NAME C OR NAME O OR NAME CB
)) OR RESSEQ 374 OR (RESID 375 AND (NAME
N OR NAME CA OR NAME C OR NAME O OR NAME
CB )) OR RESSEQ 376 OR (RESID 377 AND
(NAME N OR NAME CA OR NAME C OR NAME O OR
NAME CB )) OR RESSEQ 378:379 OR (RESID
381 AND (NAME N OR NAME CA OR NAME C OR
NAME O OR NAME CB )) OR RESSEQ 382 OR
(RESID 383 AND (NAME N OR NAME CA OR NAME
C OR NAME O OR NAME CB )) OR RESSEQ 384
OR RESSEQ 386 OR RESSEQ 388:390 OR (RESID
391 AND (NAME N OR NAME CA OR NAME C OR
NAME O OR NAME CB OR NAME CG OR NAME CD ))
OR RESSEQ 392:403 OR RESSEQ 405:418 OR
(RESID 419 AND (NAME N OR NAME CA OR NAME
C OR NAME O OR NAME CB OR NAME CG OR NAME
CD )) OR RESSEQ 420:423 OR (RESID 424 AND
(NAME N OR NAME CA OR NAME C OR NAME O OR
NAME CB )) OR RESSEQ 425:429 OR (RESID
430 AND (NAME N OR NAME CA OR NAME C OR
NAME O OR NAME CB )) OR RESSEQ 431:433 OR
(RESID 434 AND (NAME N OR NAME CA OR NAME
C OR NAME O OR NAME CB )) OR RESSEQ 435:
439 OR (RESID 440 AND (NAME N OR NAME CA
OR NAME C OR NAME O OR NAME CB OR NAME CG
OR NAME CD )) OR RESSEQ 441 OR (RESID 442
AND (NAME N OR NAME CA OR NAME C OR NAME
O OR NAME CB )) OR RESSEQ 443:446 OR
(RESID 447 AND (NAME N OR NAME CA OR NAME
C OR NAME O OR NAME CB )) OR RESSEQ 448:
450 OR (RESID 451 AND (NAME N OR NAME CA
OR NAME C OR NAME O OR NAME CB OR NAME CG
OR NAME CD )) OR (RESID 452 AND (NAME N
OR NAME CA OR NAME C OR NAME O OR NAME CB
)) OR RESSEQ 453:455))

(CHAIN H AND ((RESID 4 AND (NAME N OR
NAME CA OR NAME C OR NAME O OR NAME CB ))
OR RESSEQ 5:8 OR (RESID 9 AND (NAME N OR
NAME CA OR NAME C OR NAME O OR NAME CB ))
OR RESSEQ 10:12 OR (RESID 14 AND (NAME N
OR NAME CA OR NAME C OR NAME O OR NAME CB
)) OR (RESID 15 AND (NAME N OR NAME CA OR
NAME C OR NAME O OR NAME CB )) OR RESSEQ
16 OR (RESID 17 AND (NAME N OR NAME CA OR
NAME C OR NAME O OR NAME CB OR NAME CG ))
OR RESSEQ 18:19 OR (RESID 20 AND (NAME N
OR NAME CA OR NAME C OR NAME O OR NAME CB
)) OR (RESID 21 AND (NAME N OR NAME CA OR
NAME C OR NAME O OR NAME CB )) OR RESSEQ
22 OR (RESID 23 AND (NAME N OR NAME CA OR
NAME C OR NAME O OR NAME CB )) OR RESSEQ
24:30 OR RESSEQ 32:33 OR (RESID 34 AND
(NAME N OR NAME CA OR NAME C OR NAME O OR
NAME CB )) OR RESSEQ 35:40 OR (RESID 41
AND (NAME N OR NAME CA OR NAME C OR NAME
O OR NAME CB )) OR RESSEQ 42:46 OR (RESID
47 AND (NAME N OR NAME CA OR NAME C OR
NAME O OR NAME CB OR NAME CG OR NAME CD
OR NAME NE )) OR RESSEQ 48:52 OR (RESID
53 AND (NAME N OR NAME CA OR NAME C OR
NAME O OR NAME CB )) OR RESSEQ 54:58 OR
(RESID 59 AND (NAME N OR NAME CA OR NAME
C OR NAME O OR NAME CB )) OR RESSEQ 60:91
OR RESSEQ 93 OR RESSEQ 95 OR RESSEQ 98:
100 OR (RESID 101 AND (NAME N OR NAME CA
OR NAME C OR NAME O OR NAME CB OR NAME CG
OR NAME ND2)) OR RESSEQ 102:107 OR (RESID
108 AND (NAME N OR NAME CA OR NAME C OR
NAME O OR NAME CB )) OR (RESID 110 AND
(NAME N OR NAME CA OR NAME C OR NAME O OR
NAME CB )) OR RESSEQ 111:112 OR (RESID
113 AND (NAME N OR NAME CA OR NAME C OR
NAME O OR NAME CB )) OR RESSEQ 114:135 OR
(RESID 136 AND (NAME N OR NAME CA OR NAME
C OR NAME O OR NAME CB )) OR RESSEQ 137:
166 OR (RESID 169 AND (NAME N OR NAME CA
OR NAME C OR NAME O OR NAME CB )) OR
RESSEQ 170 OR RESSEQ 172:173 OR (RESID
174 AND (NAME N OR NAME CA OR NAME C OR
NAME O OR NAME CB )) OR (RESID 175 AND
(NAME N OR NAME CA OR NAME C OR NAME O OR
NAME CB OR NAME OG1)) OR RESSEQ 176:188
OR RESSEQ 190:191 OR RESSEQ 193 OR (RESID
194 AND (NAME N OR NAME CA OR NAME C OR
NAME O OR NAME CB )) OR (RESID 195 AND
(NAME N OR NAME CA OR NAME C OR NAME O OR
NAME CB )) OR RESSEQ 196:198 OR (RESID
199 AND (NAME N OR NAME CA OR NAME C OR
NAME O OR NAME CB )) OR RESSEQ 200:201 OR
(RESID 204 AND (NAME N OR NAME CA OR NAME
C OR NAME O OR NAME CB )) OR RESSEQ 205:
206 OR (RESID 207 AND (NAME N OR NAME CA
OR NAME C OR NAME O OR NAME CB )) OR
RESSEQ 208:209 OR (RESID 210 AND (NAME N
OR NAME CA OR NAME C OR NAME O OR NAME CB
)) OR RESSEQ 211:212 OR (RESID 213 AND
(NAME N OR NAME CA OR NAME C OR NAME O OR
NAME CB )) OR (RESID 214 AND (NAME N OR
NAME CA OR NAME C OR NAME O OR NAME CB ))
OR RESSEQ 216 OR (RESID 217 AND (NAME N
OR NAME CA OR NAME C OR NAME O OR NAME CB
)) OR (RESID 218 AND (NAME N OR NAME CA
OR NAME C OR NAME O OR NAME CB )) OR
RESSEQ 219:223 OR RESSEQ 230:238 OR
(RESID 239 AND (NAME N OR NAME CA OR NAME
C OR NAME O OR NAME CB )) OR RESSEQ 240
OR (RESID 242 AND (NAME N OR NAME CA OR
NAME C OR NAME O OR NAME CB )) OR RESSEQ
243 OR (RESID 244 AND (NAME N OR NAME CA
OR NAME C OR NAME O OR NAME CB )) OR
(RESID 245 AND (NAME N OR NAME CA OR NAME
C OR NAME O OR NAME CB )) OR RESSEQ 246
OR RESSEQ 248:250 OR (RESID 251 AND (NAME
N OR NAME CA OR NAME C OR NAME O OR NAME
CB )) OR RESSEQ 253:254 OR RESSEQ 256:287
OR (RESID 288 AND (NAME N OR NAME CA OR
NAME C OR NAME O OR NAME CB )) OR (RESID
289 AND (NAME N OR NAME CA OR NAME C OR
NAME O OR NAME CB )) OR RESSEQ 290:291 OR
RESSEQ 293:301 OR (RESID 302 AND (NAME N
OR NAME CA OR NAME C OR NAME O OR NAME CB
)) OR RESSEQ 303:308 OR (RESID 309 AND
(NAME N OR NAME CA OR NAME C OR NAME O OR
NAME CB )) OR (RESID 310 AND (NAME N OR
NAME CA OR NAME C OR NAME O OR NAME CB ))
OR RESSEQ 311 OR RESSEQ 313:336 OR (RESID
337 AND (NAME N OR NAME CA OR NAME C OR
NAME O OR NAME CB )) OR RESSEQ 338:343 OR
(RESID 344 AND (NAME N OR NAME CA OR NAME
C OR NAME O OR NAME CB )) OR RESSEQ 345:
347 OR (RESID 348 AND (NAME N OR NAME CA
OR NAME C OR NAME O OR NAME CB )) OR
(RESID 349 AND (NAME N OR NAME CA OR NAME
C OR NAME O OR NAME CB )) OR RESSEQ 350
OR (RESID 351 AND (NAME N OR NAME CA OR
NAME C OR NAME O OR NAME CB )) OR (RESID
352 AND (NAME N OR NAME CA OR NAME C OR
NAME O OR NAME CB OR NAME CG OR NAME CD ))
OR RESSEQ 353:363 OR RESSEQ 365:368 OR
RESSEQ 370:372 OR (RESID 373 AND (NAME N
OR NAME CA OR NAME C OR NAME O OR NAME CB
)) OR RESSEQ 374 OR (RESID 375 AND (NAME
N OR NAME CA OR NAME C OR NAME O OR NAME
CB )) OR RESSEQ 376 OR (RESID 377 AND
(NAME N OR NAME CA OR NAME C OR NAME O OR
NAME CB )) OR RESSEQ 378:379 OR (RESID
381 AND (NAME N OR NAME CA OR NAME C OR
NAME O OR NAME CB )) OR RESSEQ 382:384 OR
RESSEQ 386 OR RESSEQ 388:390 OR (RESID
391 AND (NAME N OR NAME CA OR NAME C OR
NAME O OR NAME CB OR NAME CG OR NAME CD ))
OR RESSEQ 392:403 OR RESSEQ 405:418 OR
(RESID 419 AND (NAME N OR NAME CA OR NAME
C OR NAME O OR NAME CB OR NAME CG OR NAME
CD )) OR RESSEQ 420:423 OR (RESID 424 AND
(NAME N OR NAME CA OR NAME C OR NAME O OR
NAME CB )) OR RESSEQ 425:429 OR (RESID
430 AND (NAME N OR NAME CA OR NAME C OR
NAME O OR NAME CB )) OR RESSEQ 431:433 OR
(RESID 434 AND (NAME N OR NAME CA OR NAME
C OR NAME O OR NAME CB )) OR RESSEQ 435:
439 OR (RESID 440 AND (NAME N OR NAME CA
OR NAME C OR NAME O OR NAME CB OR NAME CG
OR NAME CD )) OR RESSEQ 441:446 OR (RESID
447 AND (NAME N OR NAME CA OR NAME C OR
NAME O OR NAME CB )) OR RESSEQ 448:450 OR
(RESID 451 AND (NAME N OR NAME CA OR NAME
C OR NAME O OR NAME CB OR NAME CG OR NAME
CD )) OR (RESID 452 AND (NAME N OR NAME
CA OR NAME C OR NAME O OR NAME CB )) OR
RESSEQ 453:455))

TIKEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEACDESRFDKNLSQALKFVRD
FAGDGLFTSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNY
RFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDENKRQFQEDIKVMNDLVDKIIADRKASGEQSDDLLTHMLNG
KDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNE
ALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRAC
IGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAKSKKIPLGGIPSPST