Crystal structure of PD-L1 complexed with a nanobody at 1.7 Angstron resolution

Structural basis of a novel PD-L1 nanobody for immune checkpoint blockade.

Programmed death ligand 1,B7 homolog 1,B7-H1

TGQVQLQESGGGLVQPGGSLRLSCAASGKMSSRRCMAWFRQAPGKERERVAKLLTTSGSTYLADSVKGRFTISQNNAKST
VYLQMNSLKPEDTAMYYCAADSFEDPTCTLVTSSGAFQYWGQGTQVTVSSGSMDPGGSHHHHHHHH

MAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIVYWEMEDKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGN
AALQITDVKLQDAGVYRCMISYGGADYKRITVKVNALEHHHHHH

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS

Nanobody, Programmed cell death 1 ligand 1

AFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIVYWEMEDKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNA
ALQITDVKLQDAGVYRCMISYGGADYKRITVKVNA