Mouse Tdp2 reaction product (5'-phosphorylated DNA)-abasic/THF-Mg2+ complex

4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID

Reversal of DNA damage induced Topoisomerase 2 DNA-protein crosslinks by Tdp2.

DNA (5'-D(P*(3DR)P*CP*GP*AP*AP*TP*TP*CP*G)-3')

Tyr-DNA phosphodiesterase 2,5'-tyrosyl-DNA phosphodiesterase,5'-Tyr-DNA phosphodiesterase,TRAF and TNF receptor-associated protein

SKGLEDSSTISFITWNIDGLDGCNLPERARGVCSCLALYSPDVVFLQEVIPPYCAYLKKRAASYTIITGNEEGYFTAILL
KKGRVKFKSQEIIPFPNTKMMRNLLCVNVSLGGNEFCLMTSHLESTREHSAERIRQLKTVLGKMQEAPDSTTVIFAGDTN
LRDQEVIKCGGLPDNVFDAWEFLGKPKHCQYTWDTKANNNLRIPAAYKHRFDRIFFRAEEGHLIPQSLDLVGLEKLDCGR
FPSDHWGLLCTLNVVL

PEG3350, 200mM NaOAc, 20 mM Magnesium formate, 100 mM HEPES

National Institutes of Health/National Institute of Environmental Health Sciences (NIH/NIEHS)

4GZ1 contains the same molecule complexed with a different DNA

hydrolase, dna repair, endonuclease/exonuclease/phosphatase (EEP) domain, hydrolase-dna complex

LEDSSTISFITWNIDGLDGCNLPERARGVCSCLALYSPDVVFLQEVIPPYCAYLKKRAASYTIITGNEEGYFTAILLKKG
RVKFKSQEIIPFPNTKMMRNLLCVNVSLGGNEFCLMTSHLESTREHSAERIRQLKTVLGKMQEAPDSTTVIFAGDTNLRD
QEVIKCGGLPDNVFDAWEFLGKPKHCQYTWDTKANNNLRIPAAYKHRFDRIFFRAEEGHLIPQSLDLVGLEKLDCGRFPS
DHWGLLCTLNVVL

binding site for Di-nucleotide 3DR C 1 and DC C 2

binding site for Di-nucleotide 3DR D 1 and DC D 2