The structure of the eukaryotic purine/H+ symporter, UapA, in complex with Xanthine

Structure of eukaryotic purine/H(+) symporter UapA suggests a role for homodimerization in transport activity.

MDNSIHSTDGPDSVIPNSNPKKTVRQRVRLLARHLTTREGLIGDYDYGFLFRPELPFMKKDPRAPPFFGLNEKIPVLLAF
ILGLQHALAMLAGVVTPPLIISSSLSLPSDLQQYLVSTSLIVCGLLSMVQITRFHIYKTPYYIGSGVLSVMGVSFSIISV
ASGAFNQMYSNGFCQLDEAGNRLPCPEAYGALIGTSACCALVEILLAFVPPKVIQKIFPPIVTGPTVMLIGISLIGTGFK
DWAGGSACMDDGMLCPSATAPRPLPWGSPEFIGLGFLVFVSIILCERFGAPIMKSCSVVIGLLVGCIVAAACGYFSHADI
DAAPAASFIWVKTFPLSVYGPMVLPIIAVFIICACECIGDVTATCDVSRLEVRGGTFESRIQGAVLADGINSVVAALATM
TPMTTFAQNNVVIALTRCANRWAGYCCCLILIVAGIFAKFAAAIVAIPNSVMGGMKTFLFASVVISGQAIVAKAPFTRRN
RFILTASMALGYGATLVPTWFGNVFPQTENRDLEGFENAIELVLETGFAVTAFVAMLLNAIMPAEVEEIGAVTPMPVSAH
DNRDGEAEYQSKQA

Biotechnology and Biological Sciences Research Council

membrane protein eukaryotic uric acid/xanthine H+ symporter, Transport protein

MDNSIHSTDGPDSVIPNSNPKKTVRQRVRLLARHLTTREGLIGDYDYGFLFRPELPFMKKDPRAPPFFGLNEKIPVLLAF
ILGLQHALAMLAGVVTPPLIISSSLSLPSDLQQYLVSTSLIVCGLLSMVQITRFHIYKTPYYIGSGVLSVMGVSFSIISV
ASGAFNQMYSNGFCQLDEAGNRLPCPEAYGALIGTSACCALVEILLAFVPPKVIQKIFPPIVTGPTVMLIGISLIGTGFK
DWAGGSACMDDGMLCPSATAPRPLPWGSPEFIGLGFLVFVSIILCERFGAPIMKSCSVVIGLLVGCIVAAACGYFSHADI
DAAPAASFIWVKTFPLSVYGPMVLPIIAVFIICACECIGDVTATCDVSRLEVRGGTFESRIQGAVLADGINSVVAALATM
TPMTTFAQNNGVIALTRCANRWAGYCCCLILIVAGIFAKFAAAIVAIPNSVMGGMKTFLFASVVISGQAIVAKAPFTRRN
RFILTASMALGYGATLVPTWFGNVFPQTENRDLEGFENAIELVLETGFAVTAFVAMLLNAIMPAEVEEIGAVTPMPVSAH
DNRDGEAEYQSKQA