6-substituted pyrrolo[2,3-d]pyrimidine 6-thieno-(4-methoxyphenyl)

NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE

Human dihydrofolate reductase ternary complex with a series of fluorine substituted 5-methyl-6-(4'-methoxyphenythio)[2,3-d]pyrrolo-7-ethyl-2,4-diamines

VGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELK
EPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLP
EYPGVLSDVQEEKGIKYKFEVYEKND

HYDROGENS HAVE BEEN USED IF PRESENT IN THE INPUT

dihydrofolate reductase inhibitor complex with NADPH, oxidoreductase-oxidoreductase inhibitor complex

binding site for residues NDP A 202 and SO4 A 203

binding site for residues NDP A 202 and SO4 A 204