HDM2 in complex with a 3,3-Disubstituted Piperidine

Discovery of Novel 3,3-Disubstituted Piperidines as Orally Bioavailable, Potent, and Efficacious HDM2-p53 Inhibitors.

Double minute 2 protein,Hdm2,Oncoprotein Mdm2,p53-binding protein Mdm2

SQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLYYLGQYIMTKRLYDEKQQHIVHCSNDLLGDLFGVPSFSVKEH
RKIYTMIYRNLVVVNQQESSDSGTSVSEN

1.8-2.2 M ammonium sulfate, 100 mM Na Citrate/citric acid

Oncology, E3 ubiquitin-protein ligase, p53/TP53, ligase-ligase inhibitor complex

SQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEH
RKIYTMIYRNLVVVNQQESSDSGTSVSEN