Crystal Structure of Pyrococcus abyssi Trm5a complexed with adenosine

Crystal structures of the bifunctional tRNA methyltransferase Trm5a

tRNA (guanine(37)-N1)-methyltransferase Trm5a

M1G-methyltransferase,tRNA [GM37] methyltransferase

MGSSHHHHHHLEVLFQGPHMSGVKVRREDAKKVLELLKSVGILDGKRKAIRDEKYVIFPVTDTNIAKSLGLEVVDVELPM
RPERQIYKNLEDLLPREIFKKLGRLDIVGDIAIVSIPDEILSEREVIVSAIRKLYPKVKVIARRGFHSGLYRIRELEVIW
GENRLHTIHKENGVLIKVDLSKVFFNPRMKGERYRIAQLVNDGERILVPFAGVIPYPLVIARFKNVEVYAVEINEFAVKL
AEENLELNRDRLKGKIKIIHGDVFEVLPNLPNFDRVVSPTPKGVDALSLTLSKAEKFLHYYDFVHESEIERFRERVLEEC
RRQGKECRVSVRKVSDYKPHVYKVCADVEILS

Science and Technology Program of Guangzhou

Fundamental Research Funds for the Central Universities

Methyltransferase, Trm5a, SAM, Adenosine, tRNA modification, TRANSFERASE

MSGVKVRREDAKKVLELLKSVGILDGKRKAIRDEKYVIFPVTDTNIAKSLGLEVVDVELPMRPERQIYKNLEDLLPREIF
KKLGRLDIVGDIAIVSIPDEILSEREVIVSAIRKLYPKVKVIARRGFHSGLYRIRELEVIWGENRLHTIHKENGVLIKVD
LSKVFFNPRMKGERYRIAQLVNDGERILVPFAGVIPYPLVIARFKNVEVYAVEINEFAVKLAEENLELNRDRLKGKIKII
HGDVFEVLPNLPNFDRVVSPTPKGVDALSLTLSKAEKFLHYYDFVHESEIERFRERVLEECRRQGKECRVSVRKVSDYKP
HVYKVCADVEILS