Crystal structure of the G338E mutant of human apoptosis inducing factor

Structure/Function Relations in Aifm1 Variants Associated with Neurodegenerative Disorders.

RESIDUES 104-125,531-558 AND 613-617 IN CHAIN A AND 104-125 AND 531-557 IN CHAIN B ARE DISORDERED. EACH CHAIN HAS 4 ADDITIONAL C-TERMINAL RESIDUES L614-V615- P616-R617, PART OF THE THROMBIN CLEAVAGE SITE
APOPTOSIS-INDUCING FACTOR 1, MITOCHONDRIAL

PROGRAMMED CELL DEATH PROTEIN 8, APOPTOSIS INDUCING FACTOR

GLTPEQKQKKAALSASEGEEVPQDKAPSHVPFLLIGGGTAAFAAARSIRARDPGARVLIVSEDPELPYMRPPLSKELWFS
DDPNVTKTLRFKQWNGKERSIYFQPPSFYVSAQDLPHIENGGVAVLTGKKVVQLDVRDNMVKLNDGSQITYEKCLIATGG
TPRSLSAIDRAGAEVKSRTTLFRKIGDFRSLEKISREVKSITIIGGGFLGSELACALGRKARALGTEVIQLFPEKENMGK
ILPEYLSNWTMEKVRREGVKVMPNAIVQSVGVSSGKLLIKLKDGRKVETDHIVAAVGLEPNVELAKTGGLEIDSDFGGFR
VNAELQARSNIWVAGDAACFYDIKLGRRRVEHHDHAVVSGRLAGENMTGAAKPYWHQSMFWSDLGPDVGYEAIGLVDSSL
PTVGVFAKATAQDNPKSATEQSGTGIRSESETESEASEITIPPSTPAVPQAPVQGEDYGKGVIFYLRDKVVVGIVLWNIF
NRMPIARKIIKDGEQHEDLNEVAKLFNIHEDLVPR

0.2 M LITHIUM SULFATE, 0.1M TRIS, PH 8.5, AND 25% POLY-ETHYLENE GLYCOL 3350

CRYSTAL STRUCTURE OF THE V243L MUTANT OF HUMAN APOPTOSIS INDUCING FACTOR

CRYSTAL STRUCTURE OF THE G262S MUTANT OF HUMAN APOPTOSIS INDUCING FACTOR

CRYSTAL STRUCTURE OF THE G308E MUTANT OF HUMAN APOPTOSIS INDUCING FACTOR

G338E MUTATION AND 4 ADDITIONAL C-TERMINAL RESIDUES L614-
V615-P616-R617
G338E MUTATION AND 4 ADDITIONAL C-TERMINAL RESIDUES L614-
V615-P616-R617

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS.

MITOCHONDRIA, FLAVOPROTEIN, OXIDOREDUCTASE