Small-Molecule CD4-Mimics: Structure-Based Optimization of HIV-1 Entry Inhibition.

ENVELOPE GLYCOPROTEIN GP120 of HIV-1 clade C

KTTLFCASDAKAYEKEVHNVWATHACVPTDPNPQEMVLANVTENFNMWKNDMVEQMHEDIISLWDESLKPCVKLTGGSAI
TQACPKVSFDPIPLHYCAPAGFAILKCNNKTFNGTGPCRNVSTVQCTHGIKPVVSTQLLLNGSLAEEEIIIRSENLTNNA
KTIIVHLNESVNIVCTRPNNGGSGSGGNIRQAHCNINESKWNNTLQKVGEELAKHFPSKTIKFEPSSGGDLEITTHSFNC
RGEFFYCNTSDLFNGTYRNGTYNHTGRSSNGTITLQCKIKQIINMWQEVGRAIYAPPIEGEITCNSNITGLLLLRDGGND
DNDTETFRPGGGDMRDNWRSELYKYKVVEI

Crystal structure of HIV-1 gp120 complex with JP-III-048, VIRAL PROTEIN