Crystal structure of Human Spt16 N-terminal domain

Structure of the human histone chaperone FACT Spt16 N-terminal domain.

Chromatin-specific transcription elongation factor 140 kDa subunit,FACT 140 kDa subunit,FACTp140,Facilitates chromatin transcription complex subunit SPT16,hSPT16

AVTLDKDAYYRRVKRLYSNWRKGEDEYANVDAIVVSVGVDEEIVYAKSTALQTWLFGYELTDTIMVFCDDKIIFMASKKK
VEFLKQIANTKGNENANGAPAITLLIREKNESNKSSFDKMIEAIKESKNGKKIGVFSKDKFPGEFMKSWNDCLNKEGFDK
IDISAVVAYTIAVKEDGELNLMKKAASITSEVFNKFFKERVMEIVDADEKVRHSKLAESVEKAIEEKKYLAGADPSTVEM
CYPPIIQSGGNYNLKFSVVSDKNHMHFGAITCAMGIRFKSYCSNLVRTLMVDPSQEVQENYNFLLQLQEELLKELRHGVK
ICDVYNAVMDVVKKQKPELLNKITKNLGFGMGIEFREGSLVINSKNQYKLKKGMVFSINLGFSDLTNKEGKKPEEKTYAL
FIGDTVLVDEDGPATVLTSVKKKVKNVGIFL

17% (w/v) PEG 3350, 0.1 M ammonium iodide and 0.1 M sodium acetate pH 5

pita-bread, aminopeptidase, chromatin, replication, FACT, histone binding module, Chromosomal protein, DNA damage, DNA repair, DNA replication, Nucleus, Transcription, Transcription regulation