Crystal structure of anti-TAU antibody AT8 FAB

Epitope mapping and structural basis for the recognition of phosphorylated tau by the anti-tau antibody AT8.

DIVMTQAAPSVPVTPGESVSISCRSSKSLLHSNGNTYLYWFLQRPGQSPQLLIHRMSNLASGVPDRFSGSGSGTAFTLRI
SRVEAEDVGVYYCMQHLEYPYTFGGGTRLEVKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQ
SGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC

DVQLQESGPGLVKPSQSLSLTCSVTDYSITSGYYWNWIRQFPGNKLEWMGYISYDGSNNYNPSLKNRISITRDPSKDQFF
LNLNSVTTEDTATYYCTRGSLVWGQGTLVTVSAASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALT
SGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCHHHHHH

20% PEG 3350, 0.2 M CALCIUM CHLORIDE, 20% PEG 3350, 0.2 M CALCIUM CHLORIDE, 25% GLYCEROL