Crystal structure of the ornithine aminotransferase from Toxoplasma gondii ME49 in a complex with gabaculine

Center for Structural Genomics of Infectious Diseases (CSGID)

3-[O-PHOSPHONOPYRIDOXYL]--AMINO-BENZOIC ACID

Ornithine aminotransferase, mitochondrial

MATKSDGSASAAAEGGARKTNIEAYRDGLKLKTEEDFFACDRQYVCQNYAPVPVVISKGKGARVWDINGNEYYDFLAGVS
SLSQGHCHPRVIAALCRQAERLTLTLRAFGNDVTGPACRFMAEMFGYDRVLLMNTGAEAGESALKIARKWAYEVKEIPPD
SAKVILCNNNYWGRTITACSSSTTFDCYNNFGPFTPGFELIDYDDVGALEEALKDPNVAAFFVEPIQGEGGVNVPKPGYL
KRAHELCRSKNVLLIVDEIQTGLCRTGRLLAADHDEVHPDILLLGKSLSAGVVPISAVMGRADVMDVLKPGTHGSTFGGN
PLACAVAVEALTVLKDEKLADRAERLGAQFRDCLRRELYGKVPWIKEIRGRGLLNAVEVDSDAIDPNDVVMKLKENGILS
KPTRGRVMRFIPPLVITDEEHRDATTRIIKSFLAVEEERKK

0.2 M AmmSO4, 0.1 M Bis-Tris, 25% PEG3350, 5mM gabaculine and 2mM PLP

Center for Structural Genomics of Infectious Diseases
NIAID, National Institute of Allergy and Infectious Diseases

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS

inhibitor, complex, parasite, PYRIDOXAL 5'-PHOSPHATE, Structural Genomics, Center for Structural Genomics of Infectious Diseases, CSGID, TRANSFERASE