Varying binding modes of inhibitors and structural differences in the binding pockets of different gamma-glutamyltranspeptidases

(2S)-amino[(5S)-4,5-dihydro-1,2-oxazol-5-yl]acetic acid

MRRSFLKTIGLGVIALFLGLLNPLSAASYPPIKNTKVGLALSSHPLASEIGQKVLEEGGNAIDAAVAIGFALAVVHPAAG
NIGGGGFAVIHLANGENVALDFREKAPLKATKNMFLDKQGNVVPKLSEDGYLAAGVPGTVAGMEAMLKKYGTKKLSQLID
PAIKLAENGYAISQRQAETLKEARERFLKYSSSKKYFFKKGHLDYQEGDLFVQKDLAKTLNQIKTLGAKGFYQGQVAELI
EKDMKKNGGIITKEDLASYNVKWRKPVVGSYRGYKIISMSPPSSGGTHLIQILNVMENADLSALGYGASKNIHIAAEAMR
QAYADRSVYMGDADFVSVPVDKLINKAYAKKIFDTIQPDTVTPSSQIKPGMGQLHEGSN

TTHYSVADRWGNAVSVTYTINASYGSAASIDGAGFLLNNEMDDFSIKPGNPNLYGLVGGDANAIEANKRPLSSMSPTIVL
KNNKVFLVVGSPGGSRIITTVLQVISNVIDYNMNISEAVSAPRFHMQWLPDELRIEKFGMPADVKDNLTKMGYQIVTKPV
MGDVNAIQVLPKTKGSVFYGSTDPRKEFGTGSKLAAAQLYTRASQPELAPEDPEDLEHHHHHHHH

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS U VALUES : REFINED INDIVIDUALLY

gamma-GLUTAMYLTRANSPEPTIDASE, NTN-HYDROLASE, Acivicin, PROTEROS BIOSTRUCTURES GMBH, hydrolase

TTHYSVADRWGNAVSVTYTINASYGSAASIDGAGFLLNNEMDDFSIKPGNPNLYGLVGGDANAIEANKRPLSSMSPTIVL
KNNKVFLVVGSPGGSRIITTVLQVISNVIDYNMNISEAVSAPRFHMQWLPDELRIEKFGMPADVKDNLTKMGYQIVTKPV
MGDVNAIQVLPKTKGSVFYGSTDPRKEF

binding site for Di-peptide 4UD D 701 and THR D 380